EP 1807085 B1 20130821 - Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
Title (en)
Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
Title (de)
Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren
Title (fr)
Dérivés hétérocycliques et leur utilisation en tant qu'agents thérapeutiques
Publication
Application
Priority
- US 2005034129 W 20050920
- US 61164404 P 20040920
Abstract (en)
[origin: WO2006034440A2] Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, V R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>5a</SUP>, R<SUP>6</SUP>, R<SUP>6a</SUP>, R<SUP>7</SUP>, R<SUP>7a</SUP>, R<SUP>8</SUP> and R<SUP>8a</SUP> are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
IPC 8 full level
A61K 31/496 (2006.01); A61K 31/501 (2006.01); A61P 1/16 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); C07D 403/00 (2006.01)
CPC (source: EP US)
A61K 31/496 (2013.01 - EP US); A61K 31/501 (2013.01 - EP US); A61P 1/16 (2017.12 - EP); A61P 3/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 5/50 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
Citation (examination)
- US 5001125 A 19910319 - STOKBROEKX RAYMOND A [BE], et al
- CASTRO M ET AL: "Pyridazine derivatives XII. Synthesis and antipsychotic-antidepressant activity of some butyrophenone derivatives of 6-phenylpyridazine", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 29, no. 11, 1 January 1994 (1994-01-01), pages 831 - 839, XP023871023, ISSN: 0223-5234, [retrieved on 19940101], DOI: 10.1016/0223-5234(94)90106-6
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006034440 A2 20060330; WO 2006034440 A3 20060810; AR 051092 A1 20061220; AU 2005286647 A1 20060330; BR PI0515505 A 20080729; CA 2580855 A1 20060330; CN 101083994 A 20071205; EP 1807085 A2 20070718; EP 1807085 B1 20130821; EP 2266569 A2 20101229; EP 2266569 A3 20110309; JP 2008513514 A 20080501; JP 4958786 B2 20120620; MX 2007003325 A 20070605; TW 200626154 A 20060801; US 2008096895 A1 20080424; US 7767677 B2 20100803
DOCDB simple family (application)
US 2005034129 W 20050920; AR P050103906 A 20050920; AU 2005286647 A 20050920; BR PI0515505 A 20050920; CA 2580855 A 20050920; CN 200580039790 A 20050920; EP 05815243 A 20050920; EP 10013035 A 20050920; JP 2007532681 A 20050920; MX 2007003325 A 20050920; TW 94132513 A 20050920; US 57564005 A 20050920