Global Patent Index - EP 1807099 A2

EP 1807099 A2 20070718 - Y2 SELECTIVE RECEPTOR AGONISTS FOR THERAPEUTIC INTERVENTIONS

Title (en)

Y2 SELECTIVE RECEPTOR AGONISTS FOR THERAPEUTIC INTERVENTIONS

Title (de)

Y2-SELEKTIVE REZEPTORAGONISTEN FÜR THERAPEUTISCHE INTERVENTIONEN

Title (fr)

AGONISTES SELECTIFS DU RECEPTEUR Y2 UTILISES DANS DES INTERVENTIONS THERAPEUTIQUES

Publication

EP 1807099 A2 20070718 (EN)

Application

EP 05730285 A 20050317

Priority

  • EP 2005002981 W 20050317
  • DK PA200400436 A 20040317
  • US 55893204 P 20040401
  • US 58596404 P 20040706
  • GB 0500586 A 20050112

Abstract (en)

[origin: WO2005089789A2] Y receptor agonists other than PYY 3-36, which are selective for the Y2 receptor over the Y1 and Y4 receptors, and their use in the treatment of conditions responsive to activation of Y2 receptors, are disclosed. Broadly, a Y2-selective agonist is one which (a) is a PP-fold peptide or PP-fold peptide mimic selected from PYY, NPY, PYY mimics and NPY mimics which have a C-terminal Y2 receptor-recognition amino acid sequence and have various modifications relative to the natural peptides or (b) a PP-fold peptide or PP-fold peptide mimic selected from PP and PP-mimics which have a C-terminal Y2 receptor-recognition amino acid sequence and which have various modifications relative to the natural peptide or (c) comprise a C-terminal Y2 receptor-recognition amino acid sequence fused at its N-terminus to an amphiphilic amino acid sequence domain comprising at least one alpha helical turn adjacent the N-terminus of the said Y2 receptor-recognition sequence, said turn being constrained in a helical configuration by a covalent intramolecular link, and (ii), in the case where the agonist has an N-terminal structure analogous to NPY or PYY, having one or more of the modifications listed in (a) above and, in the case where the agonist has an N-terminal structure analogous to PP, having one or more of the modifications listed in (b) above.

IPC 8 full level

A61K 38/00 (2006.01); A61K 8/00 (2006.01); A61K 38/17 (2006.01); A61P 3/04 (2006.01); A61P 9/00 (2006.01); C07K 14/05 (2006.01); C07K 14/705 (2006.01)

CPC (source: EP)

A61K 38/22 (2013.01); A61P 1/04 (2017.12); A61P 1/16 (2017.12); A61P 3/04 (2017.12); A61P 3/06 (2017.12); A61P 3/08 (2017.12); A61P 3/10 (2017.12); A61P 5/50 (2017.12); A61P 7/02 (2017.12); A61P 9/00 (2017.12); A61P 9/04 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 9/14 (2017.12); A61P 11/16 (2017.12); A61P 15/00 (2017.12); A61P 17/00 (2017.12); A61P 17/02 (2017.12); A61P 19/00 (2017.12); A61P 19/02 (2017.12); A61P 19/10 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 14/70571 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 2005089789A2

Citation (examination)

  • MENTLEIN R. ET AL: "Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV", REGULATORY PEPTIDES, ELSEVIER SCIENCE BV, NL LNKD- DOI:10.1016/0167-0115(93)90435-B, vol. 49, no. 2, 10 December 1993 (1993-12-10), pages 133 - 144, XP025209058, ISSN: 0167-0115, [retrieved on 19931210]
  • MEDEIROS M.D.S. ET AL: "Processing and metabolism of peptide-YY: Pivotal roles of dipeptidylpeptidase-IV, aminopeptidase-P, and endopeptidase-24.11", ENDOCRINOLOGY 199405 US LNKD- DOI:10.1210/EN.134.5.2088, vol. 134, no. 5, May 1994 (1994-05-01), pages 2088 - 2094, XP008122547, ISSN: 0013-7227
  • YOSHINAGA K. ET AL: "Structural requirements of peptide YY for biological activity at enteric sites.", THE AMERICAN JOURNAL OF PHYSIOLOGY NOV 1992 LNKD- PUBMED:1443144, vol. 263, no. 5 PT 1, November 1992 (1992-11-01), pages G695 - G701, XP008052441, ISSN: 0002-9513

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2005089789 A2 20050929; WO 2005089789 A3 20060209; AU 2005224026 A1 20050929; BR PI0507585 A 20070703; CA 2559838 A1 20050929; EA 011860 B1 20090630; EA 200601721 A1 20070427; EP 1807099 A2 20070718; EP 2272524 A2 20110112; EP 2272524 A3 20110202; IL 177683 A0 20061231; JP 2007531713 A 20071108; MX PA06010347 A 20070619

DOCDB simple family (application)

EP 2005002981 W 20050317; AU 2005224026 A 20050317; BR PI0507585 A 20050317; CA 2559838 A 20050317; EA 200601721 A 20050317; EP 05730285 A 20050317; EP 10075185 A 20050317; IL 17768306 A 20060824; JP 2007503301 A 20050317; MX PA06010347 A 20050317