EP 1809298 A4 20080618 - NEUROPROTECTIVE SPIROSTENOL PHARMACEUTICAL COMPOSITIONS
Title (en)
NEUROPROTECTIVE SPIROSTENOL PHARMACEUTICAL COMPOSITIONS
Title (de)
NEUROPROTEKTIVE PHARMAZEUTISCHE SPIROSTENOL-ZUSAMMENSETZUNGEN
Title (fr)
COMPOSITIONS PHARMACEUTIQUES NEUROPROTECTRICES CONTENANT DU SPIROSTENOL
Publication
Application
Priority
- US 2005037023 W 20051014
- US 61869604 P 20041014
- US 3153805 A 20050107
Abstract (en)
[origin: WO2006044665A2] The present invention relates to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a disorder or disease related to, or the symptoms associated with a neurodegenerative disorder such as neurotoxicity or a neuropathology in a subject, particularly to beta-amyloid-induced neurotoxicity and Alzheimer's disease. The invention further provides a method for inducing stem cell differentiation into neuronal cells, by administering to the patient a therapeutically effective amount of a compound of the invention.
IPC 8 full level
A01N 45/00 (2006.01); A61K 31/56 (2006.01); A61K 31/58 (2006.01); A61K 31/585 (2006.01); A61K 31/59 (2006.01); A61P 25/28 (2006.01)
CPC (source: EP)
A61K 31/56 (2013.01); A61K 31/58 (2013.01); A61K 31/585 (2013.01); A61K 31/59 (2013.01); A61P 9/00 (2017.12); A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/08 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/22 (2017.12); A61P 25/28 (2017.12); A61P 31/22 (2017.12)
Citation (search report)
- [X] WO 03077869 A2 20030925 - SAMARITAN PHARMACEUTICALS INC [US], et al
- [X] WO 0211708 A2 20020214 - SYMPHAR SA [CH], et al
- [X] YAO Z-X ET AL: "22R-Hydroxycholesterol Protects Neuronal Cells from Beta-Amyloid-Induced Cytotoxicity by Binding to Beta-Amyloid Peptide", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 83, 2002, pages 1110 - 1119, XP003015166, ISSN: 0022-3042
- [X] KOLDAMOVA R P, LEFTEROV I M, IKONOMOVIC M D, SKOKO J, LEFTEROV P I, ISANSKI B A, DEKOSKY S T, LAZO J S: "22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 15, 11 April 2003 (2003-04-11), pages 13244 - 13256, XP002476236
- [Y] LECANU L ET AL: "Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity", STEROIDS, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 69, no. 1, January 2004 (2004-01-01), pages 1 - 16, XP004484607, ISSN: 0039-128X
- [Y] LIU ZHONGRONG ET AL: "Preparation of carboxylate and monoester succinate derivatives of diosgenin and their bioactivities for treating and preventing cerebrovascular and cardiovascular diseases", HCAPLUS, 23 October 2003 (2003-10-23), XP002391897 & WO 03086411 A1 20031023 - CHENGDU DI AO PHARMACEUTICAL G [CN], et al
- See references of WO 2006044665A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006044665 A2 20060427; WO 2006044665 A3 20070705; AU 2005295617 A1 20060427; CA 2584333 A1 20060427; EP 1809298 A2 20070725; EP 1809298 A4 20080618; JP 2008516972 A 20080522
DOCDB simple family (application)
US 2005037023 W 20051014; AU 2005295617 A 20051014; CA 2584333 A 20051014; EP 05812949 A 20051014; JP 2007536942 A 20051014