Global Patent Index - EP 1812063 A4

EP 1812063 A4 2009-02-11 - MONOCLONAL ANTIBODIES TO THE PROPEPTIDE OF CANDIDA ALBICANS AND METHODS OF USE

Title (en)

MONOCLONAL ANTIBODIES TO THE PROPEPTIDE OF CANDIDA ALBICANS AND METHODS OF USE

Title (de)

MONOKLONALE ANTIKÖRPER GEGEN DAS PROPEPTID AUS CANDIDA ALBICANS UND VERWENDUNGSVERFAHREN

Title (fr)

ANTICORPS MONOCLONAUX DU PROPEPTIDE DU CANDIDA ALBICANS, ET SES PROCÉDÉS D'UTILISATION

Publication

EP 1812063 A4 (EN)

Application

EP 05825759 A

Priority

  • US 2005039431 W
  • US 62284504 P

Abstract (en)

[origin: WO2006050343A2] Monoclonal antibodies which can bind to the propeptide of the Int1p protein of yeast microorganisms such as Candida albicans are provided which<I/>can be useful in methods for treating or preventing infections arising from such microorganisms. In particular, monoclonal antibodies are provided which can recognize the epitope located at amino acids 252-260 on the Intl p protein, and such monoclonal antibodies can recognize the propeptide region of Int1 p as well as the complete Int1 p protein. Such antibodies are effective in blocking of the activation of T-lymphocytes, blocking the expansion of T-cells bearing V-beta subsets, such as 2, 3, 14 or others, and blocking the secretion of interferon­gamma, so as to be effective in treating or preventing infection from yeast such as Candida albicans.

IPC 8 full level (invention and additional information)

A61K 39/395 (2006.01); A61K 39/40 (2006.01); C07K 16/00 (2006.01)

CPC (invention and additional information)

G01N 33/56961 (2013.01); C07K 16/14 (2013.01); A61K 2039/505 (2013.01); G01N 2333/40 (2013.01); G01N 2469/10 (2013.01)

Citation (search report)

  • [X] WO 0226257 A1 20020404 - UNIV YALE [US]
  • [X] US 2003082680 A1 20030501 - HOSTETTER MARGARET K [US], et al
  • [X] HOSTETTER M K: "REVIEW INTEGRIN-LIKE PROTEINS IN CANDIDA SPP. AND OTHER MICROORGANISMS", FUNGAL GENETICS AND BIOLOGY, SAN DIEGO, CA, US, vol. 28, 1 January 1999 (1999-01-01), pages 135 - 145, XP002906434, ISSN: 1087-1845
  • [X] GALE C ET AL: "Cloning and expression of a gene encoding an integrin-like protein in Candida albicans.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 9 JAN 1996, vol. 93, no. 1, 9 January 1996 (1996-01-09), pages 357 - 361, XP002508457, ISSN: 0027-8424
  • [A] GALE C A ET AL: "Linkage of adhesion, filamentous growth and virulence in candida albicans to a single gene, INT1", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, WASHINGTON, DC, vol. 279, 27 February 1998 (1998-02-27), pages 1355 - 1358, XP002954887, ISSN: 0036-8075

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

EPO simple patent family

WO 2006050343 A2 20060511; WO 2006050343 A3 20061102; EP 1812063 A2 20070801; EP 1812063 A4 20090211

INPADOC legal status


2009-11-04 [R18D] EP-APPLICATION DEEMED TO BE WITHDRAWN: (CORRECTION)

- Effective date: 20090410

2009-10-28 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20090825

2009-02-11 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20090113

2008-02-06 [DAX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT (TO ANY COUNTRY) DELETED

2007-08-01 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20070521

2007-08-01 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR