EP 1817059 A2 20070815 - CONJUGATES OF 1,8-BIS-NAPHTHALIMIDES WITH AN ANTIBODY
Title (en)
CONJUGATES OF 1,8-BIS-NAPHTHALIMIDES WITH AN ANTIBODY
Title (de)
KONJUGATE VON 1,8-BIS-NAPHTHALIMIDEN MIT EINEM ANTIKÖRPER
Title (fr)
CONJUGUES DE 1,8-BIS-NAPHTHALIMIDES AVEC UN ANTICORPS
Publication
Application
Priority
- US 2005043409 W 20051129
- US 63261304 P 20041201
Abstract (en)
[origin: WO2006060533A2] The invention relates to antibody drug conjugate (ADC) compounds represented by Formula:(I) where one or more 1,8 bis-naphthalimide drug moieties (D) having Formulas (IIa) and (Ilb)are covalently linked by a linker (L) to an antibody (Ab). The invention also relates to pharmaceutical compositions comprising an effective amount of a Formula I ADC for treatment of hyperproliferative disorders and other disorders. The invention also relates to methods for killing or inhibiting the multiplication of a tumor cell or cancer cell including administering to a patient an effective amount of a Formula (I) ADC.
IPC 8 full level
A61K 47/48 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 47/6803 (2017.07); A61K 47/6849 (2017.07); A61K 47/6851 (2017.07); A61P 7/04 (2017.12); A61P 25/00 (2017.12); A61P 29/00 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 37/02 (2017.12)
Citation (search report)
See references of WO 2006060533A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
WO 2006060533 A2 20060608; WO 2006060533 A3 20070726; EP 1817059 A2 20070815; JP 2008521920 A 20080626; JP 4993645 B2 20120808
DOCDB simple family (application)
US 2005043409 W 20051129; EP 05852595 A 20051129; JP 2007544495 A 20051129