EP 1828122 A2 20070905 - N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALIN RE-UPTAKE INHIBITORS
Title (en)
N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALIN RE-UPTAKE INHIBITORS
Title (de)
N-PYRROLIDIN-3-YLAMIDDERIVATE ALS SEROTONIN- UND NORADRENALIN-WIEDERAUFNAHMEHEMMER
Title (fr)
DÉRIVÉS DE N-PYRROLIDIN-3-YL-AMIDE COMME INHIBITEURS DE RECAPTAGE DE LA SÉROTONINE ET NORADRÉNALINE
Publication
Application
Priority
- IB 2005003791 W 20051208
- GB 0427618 A 20041216
- US 64783905 P 20050127
- US 69523805 P 20050628
Abstract (en)
[origin: WO2006064351A2] A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R<SUP>1</SUP> is H, C<SUB>1-6</SUB>alkyl, -C(A)Y, C<SUB>3-8</SUB>cycloalkyl, aryl, het, aryl-C<SUB>1-4</SUB>alkyl or het-C<SUB>l-4</SUB>alkyl, wherein the cycloalkyl, aryl or het groups are optionally substituted; A is S or O; Y is H, C<SUB>1-6</SUB>alkyl, aryl, het, aryl-C<SUB>1-4</SUB>alkyl or het-C<SUB>1-4</SUB>alkyl; aryl is independently selected from phenyl, naphthyl, anthracyl or phenanthryl; het is independently selected from an aromatic or non-aromatic 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6- membered carbocyclic group or a second 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom; R<SUP>2</SUP> is aryl<SUP>1</SUP> or het<SUP>1</SUP>, each optionally substituted; aryl<SUP>1</SUP> is independently selected from phenyl, naphthyl, anthracyl, phenanthryl, or indanyl; het<SUP>1</SUP> is an aromatic 5 to 10 membered heterocyclic ring system which contains at least one N, O or S heteroatom, optionally containing an aryl group; R<SUP>3</SUP> is H, C<SUB>1-8</SUB>alkyl, C<SUB>3-8</SUB>cycloalkyl, C<SUB>3-8</SUB>cycloalkyl-C<SUB>1-6</SUB>alkyl, C<SUB>1-8</SUB>alkylSC<SUB>1-8</SUB>alkyl, het<SUP>3</SUP>, or het<SUP>3</SUP>-C<SUB>1-4</SUB>alkyl, wherein the alkyl, cycloalkyl and het<SUP>3</SUP> groups are each optionally substituted; het<SUP>3</SUP> is a non-aromatic 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6- membered carbocyclic group or a second 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom; or R<SUP>3</SUP> is (CH<SUB>2</SUB>)<SUB>a</SUB> <SUP>,</SUP>K
IPC 8 full level
A61K 31/40 (2006.01); A61P 13/00 (2006.01); A61P 25/24 (2006.01); A61P 29/00 (2006.01); C07D 207/34 (2006.01); C07D 211/58 (2006.01); C07D 401/12 (2006.01)
CPC (source: EP)
A61P 13/00 (2017.12); A61P 15/08 (2017.12); A61P 25/04 (2017.12); A61P 25/24 (2017.12); A61P 29/00 (2017.12); A61P 43/00 (2017.12); C07D 207/14 (2013.01); C07D 211/58 (2013.01); C07D 401/12 (2013.01)
Citation (search report)
See references of WO 2006064351A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006064351 A2 20060622; WO 2006064351 A3 20061012; CA 2591415 A1 20060622; EP 1828122 A2 20070905; JP 2008524200 A 20080710
DOCDB simple family (application)
IB 2005003791 W 20051208; CA 2591415 A 20051208; EP 05811385 A 20051208; JP 2007546219 A 20051208