EP 1828136 A1 20070905 - (5S) -3-[(S)-FLUORO (4-TRIFLUOROMETHYLPHENYL) METHYL]-5,6,7,8-TETRAHYDROQUINOLINE-5-OL DERIVATIVES AND USE THEREOF AS CETP INHIBITORS
Title (en)
(5S) -3-[(S)-FLUORO (4-TRIFLUOROMETHYLPHENYL) METHYL]-5,6,7,8-TETRAHYDROQUINOLINE-5-OL DERIVATIVES AND USE THEREOF AS CETP INHIBITORS
Title (de)
(5S)-3-[(S)-FLUOR(4-TRIFLUOROMETHYLPHENYL)METHYL]-5,6,7,8-TETRAHYDROCHINOLIN-5-OL DERIVATE UND IHRE VERWENDUNG ALS CETP-INHIBITOREN
Title (fr)
DERIVES DE (5S)-3-[(S)-FLUOR(4-TRIFLUOROMETHYLPHENYL)METHYL]-5,6,7,8-TETRAHYDROQUINOLEIN-5-OL, ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE DE TRANSFERT DES ESTERS DE CHOLESTEROL (CETP)
Publication
Application
Priority
- EP 2005013281 W 20051210
- DE 102004061002 A 20041218
- DE 102004061003 A 20041218
- DE 102004060999 A 20041218
- DE 102004060998 A 20041218
- DE 102004061001 A 20041218
Abstract (en)
[origin: WO2006072362A1] The invention relates to novel tetrahydroquinoline derivatives of formula (I), wherein R<SUP>1</SUP> represents cyclohexyl or cyclopentyl, R<SUP>2</SUP> and R<SUP>3</SUP> each represent methyl or jointly form a cyclobutane, and R<SUP>4</SUP> represents cyclopentyl or isopropyl, the salts and solvates thereof, and the solvates of said salts. Also disclosed are a method for the production thereof, the use thereof on its own or in combinations for the treatment and/or prevention of diseases, and the use thereof for producing medicaments, particularly as a cholesterol ester transfer protein (CETP) inhibitor in order to treat and/or prevent cardiovascular diseases, especially hypolipoproteinemia, dyslipidemia, hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, and arteriosclerosis.
IPC 8 full level
A61K 31/47 (2006.01); C07D 215/20 (2006.01)
CPC (source: EP KR US)
A61K 31/47 (2013.01 - KR); A61P 1/00 (2017.12 - EP); A61P 3/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 25/28 (2017.12 - EP); C07D 215/20 (2013.01 - EP KR US)
Citation (search report)
See references of WO 2006072362A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006072362 A1 20060713; AU 2005324127 A1 20060713; BR PI0519566 A2 20090127; CA 2591486 A1 20060713; EP 1828136 A1 20070905; JP 2008524137 A 20080710; KR 20070090192 A 20070905; MX 2007007187 A 20070814; US 2008194609 A1 20080814
DOCDB simple family (application)
EP 2005013281 W 20051210; AU 2005324127 A 20051210; BR PI0519566 A 20051210; CA 2591486 A 20051210; EP 05815944 A 20051210; JP 2007545911 A 20051210; KR 20077013485 A 20070615; MX 2007007187 A 20051210; US 79348305 A 20051210