Global Patent Index - EP 1828953 A4

EP 1828953 A4 20100526 - RIBOSWITCHES, STRUCTURE-BASED COMPOUND DESIGN WITH RIBOSWITCHES, AND METHODS AND COMPOSITIONS FOR USE OF AND WITH RIBOSWITCHES

Title (en)

RIBOSWITCHES, STRUCTURE-BASED COMPOUND DESIGN WITH RIBOSWITCHES, AND METHODS AND COMPOSITIONS FOR USE OF AND WITH RIBOSWITCHES

Title (de)

RIBOSWITCHES, STRUKTURBASIERENDES VERBINDUNGSDESIGN MIT RIBOSWITCHES UND VERFAHREN UND ZUSAMMENSETZUNGEN ZUR VERWENDUNG VON UND MIT RIBOSWITCHES

Title (fr)

RIBOCOMMUTATEURS, STRUCTURE DE COMPOSES A RIBOCOMMUTATEURS, ET METHODES ET COMPOSITIONS UTILISEES AVEC LES RIBOCOMMUTATEURS

Publication

EP 1828953 A4 20100526 (EN)

Application

EP 05851443 A 20051108

Priority

  • US 2005040487 W 20051108
  • US 62586404 P 20041108

Abstract (en)

[origin: WO2006055351A2] Riboswitches and modified versions of riboswitches can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non-immunogenic genetic control elements, for example the aptamer (molecular recognition) domain can be swapped with other non-natural aptamers (or otherwise modified) such that the new recognition domain causes genetic modulation with user-defined effector compounds. The changed switches become part of a therapy regimen-turning on, or off, or regulating protein synthesis. Newly constructed genetic regulation networks can be applied in such areas as living biosensors, metabolic engineering of organisms, and in advanced forms of gene therapy treatments. Compounds can be used to stimulate, active, inhibit and/or inactivate riboswitches. Atomic structures of riboswitches can be used to design new compounds to stimulate, active, inhibit and/or inactivate riboswitches.

IPC 8 full level

G06G 7/48 (2006.01); C07H 21/04 (2006.01); C12N 15/115 (2010.01); C12Q 1/18 (2006.01); C12Q 1/68 (2006.01)

CPC (source: EP KR US)

A61P 31/04 (2017.12 - EP); C07H 21/04 (2013.01 - EP KR US); C12N 15/115 (2013.01 - EP KR US); C12Q 1/6897 (2013.01 - EP KR US); C12N 2310/16 (2013.01 - EP KR US); C12N 2320/10 (2013.01 - EP KR US); C12Q 2565/101 (2013.01 - EP KR US); C12Q 2600/136 (2013.01 - KR); Y02A 90/10 (2017.12 - EP US)

Citation (search report)

  • [A] MANDAL M ET AL: "Gene regulation by riboswitches", NATURE REVIEWS MOLECULAR CELL BIOLOGY, NATURE PUBLISHING, GB LNKD- DOI:10.1038/NRM1403, vol. 5, 1 June 2004 (2004-06-01), pages 451 - 463, XP008121394, ISSN: 1471-0072
  • [A] MANDAL M ET AL: "Adenine riboswitches and gene activation by disruption of a transcription terminator", NATURE STRUCTURAL AND MOLECULAR BIOLOGY 200401 US LNKD- DOI:10.1038/NSMB710, vol. 11, no. 1, January 2004 (2004-01-01), pages 29 - 35, XP002577594, ISSN: 1545-9993
  • [IP] BATEY ROBERT T ET AL: "Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine.", NATURE 18 NOV 2004 LNKD- PUBMED:15549109, vol. 432, no. 7015, 18 November 2004 (2004-11-18), pages 411 - 415, XP002577595, ISSN: 1476-4687
  • [IP] SERGANOV A ET AL: "Structural Basis for Discriminative Regulation of Gene Expression by Adenine- and Guanine-Sensing mRNAs", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB LNKD- DOI:10.1016/J.CHEMBIOL.2004.11.018, vol. 11, no. 12, 1 December 2004 (2004-12-01), pages 1729 - 1741, XP004689697, ISSN: 1074-5521
  • See references of WO 2006055351A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2006055351 A2 20060526; WO 2006055351 A3 20070322; AU 2005306801 A1 20060526; AU 2005306801 A2 20060526; AU 2005306801 B2 20120517; CA 2586998 A1 20060526; CN 101111847 A 20080123; EP 1828953 A2 20070905; EP 1828953 A4 20100526; EP 1828953 B1 20130306; JP 2008518630 A 20080605; JP 2012065661 A 20120405; KR 20070111448 A 20071121; MX 2007005491 A 20070927; SG 160326 A1 20100429; US 2008269258 A1 20081030

DOCDB simple family (application)

US 2005040487 W 20051108; AU 2005306801 A 20051108; CA 2586998 A 20051108; CN 200580046277 A 20051108; EP 05851443 A 20051108; JP 2007540181 A 20051108; JP 2011239122 A 20111031; KR 20077012055 A 20070528; MX 2007005491 A 20051108; SG 2010009306 A 20051108; US 66715305 A 20051108