EP 1831236 A1 20070912 - METHOD FOR THE PREPARATION OF 2'-DEOXY-2',2'-DIFLUOROCYTIDINE
Title (en)
METHOD FOR THE PREPARATION OF 2'-DEOXY-2',2'-DIFLUOROCYTIDINE
Title (de)
VERFAHREN ZUR HERSTELLUNG VON 2'-DEOXY-2',2'-DIFLUOROCYTIDIN
Title (fr)
METHODE SERVANT A PREPARER 2'-DEOXY-2',2'-DIFLUOROCYTIDINE
Publication
Application
Priority
- KR 2005004633 W 20051229
- KR 20040116316 A 20041230
- KR 2005001954 W 20050623
Abstract (en)
[origin: WO2006071090A1] This invention relates to an improved method for stereoselectively preparing 2¢¥-deoxy-2¢¥,2¢¥-difluorocytidine of formula (I), which comprises the steps of reacting a 1-halo ribofuranose compound of formula (III) with a nucleobase of formula (IV) in a solvent to obtain a nucleoside of formula (II) with removing the silyl halide of formula (V) produced during the reaction; and deprotecting the nucleoside of formula (II) to obtain 2¢¥-deoxy-2¢¥,2¢¥-difluorocytidine of formula (I).
IPC 8 full level
C07H 19/04 (2006.01)
CPC (source: EP)
C07H 19/04 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006071090 A1 20060706; AU 2005320374 A1 20060706; AU 2005320374 B2 20090108; BR PI0514718 A 20080701; CN 101010329 A 20070801; CN 101010329 B 20110608; EP 1831236 A1 20070912; EP 1831236 A4 20131120; NO 20070865 L 20070424
DOCDB simple family (application)
KR 2005004633 W 20051229; AU 2005320374 A 20051229; BR PI0514718 A 20051229; CN 200580029086 A 20051229; EP 05823850 A 20051229; NO 20070865 A 20070215