EP 1831244 A2 20070912 - DERMORPHIN ANALOGS WITH ANALGESIC ACTIVITY
Title (en)
DERMORPHIN ANALOGS WITH ANALGESIC ACTIVITY
Title (de)
DERMORPHINANALOGA MIT ANALGETISCHER WIRKUNG
Title (fr)
ANALOGUES DE LA DERMORPHINE A ACTIVITE ANALGESIQUE
Publication
Application
Priority
- IT 2005000733 W 20051214
- IT RM20040607 A 20041215
Abstract (en)
[origin: WO2006064530A2] New opioid heptapeptide analogs of dermorphin characterised by the fact that, like dermorphin, they maintain a tyrosine residue in position 1 ans a D-a-aminoacid, preferably D-Ala, in position 2, and by the fact that in position 7 they have the aminoacid of maximum basicity, i.e. arginine. The preferred peptide of the invention, Arg<SUP>7</SUP>-dermorphin, referred to as arginorphin, has a potent analgesic activity. This activity largely comes about at the peripheral opiod nociceptor level, without involving the more serious central side effects typical of opiates.
IPC 8 full level
C07K 7/06 (2006.01)
CPC (source: EP)
C07K 7/06 (2013.01)
Citation (search report)
See references of WO 2006064530A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006064530 A2 20060622; WO 2006064530 A3 20070208; EP 1831244 A2 20070912; IT RM20040607 A1 20050315
DOCDB simple family (application)
IT 2005000733 W 20051214; EP 05823581 A 20051214; IT RM20040607 A 20041215