EP 1831693 A2 20070912 - USE OF PTA PEPTIDES FOR STRATIFICATION OF INDIVIDUALS HAVING CANCER
Title (en)
USE OF PTA PEPTIDES FOR STRATIFICATION OF INDIVIDUALS HAVING CANCER
Title (de)
VERWENDUNG VON PTA-PEPTIDEN ZUR STRATIFIZIERUNG VON AN KREBS ERKRANKTEN INDIVIDUEN
Title (fr)
UTILISATION DES PEPTIDES DE PTA POUR LA CLASSIFICATION DES INDIVIDUS AYANT LE CANCER
Publication
Application
Priority
- EP 2005013244 W 20051209
- EP 04029171 A 20041209
- EP 05818773 A 20051209
Abstract (en)
[origin: WO2006061242A2] The present invention relates to methods for the stratification of individuals suffering from cancer. In particular, the present invention relates to the finding that PTA-fragments allow the discrimination of cancer cells being susceptible to an anti-endocrine therapy from cancer cells not susceptible to said therapy. Thus, PTA-fragments can be a surrogate for estradiol receptor detection by immune histology, can be a marker to monitor resistance of cancer cells towards anti-estradiol therapy, can be used to monitor rezidives and can be used to determine the status of dedifferentiation, e.g. the state of cancer cells. PTA-fragments have the advantage to be determined from easily accessible patient samples such as serum or plasma. The present invention further encompasses specific PTA peptides and nucleic acids, antibodies therefore, test kits and diagnostic and therapeutic methods and compositions.
IPC 8 full level
G01N 33/574 (2006.01); A61P 35/00 (2006.01); C07K 14/575 (2006.01); C07K 16/26 (2006.01); C12N 5/00 (2006.01); C12N 15/00 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); G01N 33/57415 (2013.01); G01N 33/57434 (2013.01); G01N 33/57449 (2013.01); G01N 2333/5759 (2013.01); G01N 2800/52 (2013.01)
Citation (search report)
See references of WO 2006061242A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006061242 A2 20060615; WO 2006061242 A3 20060914; CA 2590196 A1 20060615; EP 1742059 A1 20070110; EP 1831693 A2 20070912; JP 2008522601 A 20080703
DOCDB simple family (application)
EP 2005013244 W 20051209; CA 2590196 A 20051209; EP 04029171 A 20041209; EP 05818773 A 20051209; JP 2007544832 A 20051209