EP 1833801 B9 20090225 - INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF ANGIOTENSIN II RECEPTOR ANTAGONISTS
Title (en)
INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF ANGIOTENSIN II RECEPTOR ANTAGONISTS
Title (de)
ZWISCHENPRODUKTE FÜR DIE HERSTELLUNG VON ANTAGONISTEN DES ANGIOTENSIN-II-REZEPTORS
Title (fr)
COMPOSES INTERMEDIAIRES POUR LA PREPARATION D'ANTAGONISTES DU RECEPTEUR DE L'ANGIOTENSINE II
Publication
Application
Priority
- EP 2005057102 W 20051222
- EP 04106861 A 20041222
- EP 05823669 A 20051222
Abstract (en)
[origin: WO2006067215A3] It comprises new substituted heterocyclic methylphenyl boronic acids and their derivatives and also its preparation process. It also comprises a preparation process of Angiotensin II (A-II) receptor antagonists from such intermediates. The process includes the step of reacting the new substituted heterocyclic methylphenyl boronic compounds with a (halophenyl)tetrazole compound which proceeds with high yields. It allows to prepare the compounds of the present invention from a common intermediate compound, a N-protected- 5-(2-halogenphenyl)-1H-tetrazole, by a process which is particularly advantageous in its practical industrial realization because it avoids the use of azide derivatives and also the use of expensive biphenyl intermediates.
IPC 8 full level
C07D 233/22 (2006.01)
CPC (source: EP KR)
C07D 233/22 (2013.01 - EP KR); C07D 233/32 (2013.01 - EP); C07D 235/02 (2013.01 - EP); C07D 403/10 (2013.01 - KR); C07F 5/025 (2013.01 - EP)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006067215 A2 20060629; WO 2006067215 A3 20061109; AT E397592 T1 20080615; DE 602005007384 D1 20080717; EP 1833801 A2 20070919; EP 1833801 B1 20080604; EP 1833801 B9 20090225; ES 2308591 T3 20081201; KR 20070089943 A 20070904; PT 1833801 E 20080825
DOCDB simple family (application)
EP 2005057102 W 20051222; AT 05823669 T 20051222; DE 602005007384 T 20051222; EP 05823669 A 20051222; ES 05823669 T 20051222; KR 20077013967 A 20070620; PT 05823669 T 20051222