Global Patent Index - EP 1835933 A4

EP 1835933 A4 20150107 - HSP60, HSP60 PEPTIDES AND T CELL VACCINES FOR IMMUNOMODULATION

Title (en)

HSP60, HSP60 PEPTIDES AND T CELL VACCINES FOR IMMUNOMODULATION

Title (de)

HSP60, HSP60-PEPTIDE UND T-ZELLEN-IMPFSTOFFE ZUR IMMUNMODULATION

Title (fr)

HSP60, PEPTIDES HSP60 ET VACCINS A BASE DE LYMPHOCYTES T POUR IMMUNOMODULATION

Publication

EP 1835933 A4 20150107 (EN)

Application

EP 06700161 A 20060104

Priority

  • IL 2006000014 W 20060104
  • US 64107505 P 20050104
  • US 67964705 P 20050511

Abstract (en)

[origin: WO2006072946A2] The present invention provides novel uses for peptide p277 - positions 437-460 of human heat shock protein 60 (HSP60) - in modulation of immune responses and inflammatory diseases. The invention further provides novel uses for HSP60 and p277 in the treatment or prevention of hepatic disorders. The invention discloses methods for treating, preventing or ameliorating the symptoms of T cell mediated inflammatory and autoimmune disorders, including hepatic disorders, which comprise administering to a subject in need thereof a composition comprising as an active ingredient an effective quantity of a molecule selected from: HSP60, p277, fragments, analogs, homologs and derivatives thereof, and nucleic acids encoding same. Also disclosed are T cell vaccination methods for treating or preventing T cell mediated disorders.

IPC 8 full level

A61K 39/00 (2006.01); A01N 65/00 (2009.01); C12N 15/09 (2006.01)

CPC (source: EP US)

A61K 35/17 (2013.01 - EP US); A61K 38/1709 (2013.01 - US); A61K 39/0008 (2013.01 - EP US); A61K 39/4611 (2023.05 - EP); A61K 39/4621 (2023.05 - EP); A61K 39/46433 (2023.05 - EP); A61K 39/464476 (2023.05 - EP); A61P 1/16 (2018.01 - EP); A61P 31/12 (2018.01 - EP); C12N 5/0636 (2013.01 - EP US); A61K 2035/124 (2013.01 - EP US); A61K 2039/5158 (2013.01 - US); A61K 2039/53 (2013.01 - EP US); A61K 2239/31 (2023.05 - EP); A61K 2239/38 (2023.05 - EP); C12N 2501/07 (2013.01 - EP US)

Citation (search report)

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  • [XA] WO 0168124 A2 20010920 - BRIGHAM & WOMENS HOSPITAL [US]
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  • [A] S. B. FLOHE ET AL: "Human Heat Shock Protein 60 Induces Maturation of Dendritic Cells Versus a Th1-Promoting Phenotype", THE JOURNAL OF IMMUNOLOGY, vol. 170, no. 5, 1 March 2003 (2003-03-01), pages 2340 - 2348, XP055155408, ISSN: 0022-1767, DOI: 10.4049/jimmunol.170.5.2340
  • [A] GIUSEPPE LEGNAME ET AL: "Expression in Escherichia coli, purification and functional activity of recombinant human chaperonin 10", FEBS LETTERS, vol. 361, no. 2-3, 1 March 1995 (1995-03-01), pages 211 - 214, XP055155401, ISSN: 0014-5793, DOI: 10.1016/0014-5793(95)00184-B
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  • [A] ELIAS D ET AL: "TREATMENT OF AUTOIMMUNE DIANETES AND INSULITIS IN NOD MICE WITH HEAT SHOCK PROTEIN 60 PEPTIDE P277", DIABETES, AMERICAN DIABETES ASSOCIATION, US, vol. 44, no. 9, 1 September 1995 (1995-09-01), pages 1132 - 1138, XP001034245, ISSN: 0012-1797, DOI: 10.2337/DIABETES.44.9.1132
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Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2006072946 A2 20060713; WO 2006072946 A3 20101229; EP 1835933 A2 20070926; EP 1835933 A4 20150107; IL 184283 A0 20081229; IL 184283 A 20150831; US 2010003225 A1 20100107; US 2014219979 A1 20140807; US 8691772 B2 20140408

DOCDB simple family (application)

IL 2006000014 W 20060104; EP 06700161 A 20060104; IL 18428307 A 20070628; US 201414221887 A 20140321; US 81333306 A 20060104