EP 1838872 A2 20071003 - CANCER-SPECIFIC SPANX-N MARKERS
Title (en)
CANCER-SPECIFIC SPANX-N MARKERS
Title (de)
KREBSSPEZIFISCHE SPANX-N-MARKER
Title (fr)
MARQUEURS SPANX-N SPECIFIQUES DU CANCER
Publication
Application
Priority
- US 2005045317 W 20051215
- US 63681104 P 20041215
Abstract (en)
[origin: WO2006065938A2] The invention provides SPANX polypeptides, nucleic acids and antibodies that are useful for detecting and treating cancer. The invention relates to a new subfamily of SPANX genes, SPANX-N1, SPANX-N2, SPANX-N3 SPANX-N4 and SPANX-N5. In contrast to the previously identified SPANX-A/D subfamily, expression of SPANX-N genes is not restricted to testis, and was detected in normal prostate, placenta, lung, colon, ovary and cervix tissues. Comparison of matched normal/tumor tissues revealed a predominant activation of only one member of the subfamily, SPANX-N1, in tumors, indicating that expression of this gene is diagnostic of cancer. Methods and reagents described herein permit detection and treatment of cancers associated with SPANX-N1 expression.
IPC 8 full level
C12Q 1/68 (2006.01)
CPC (source: EP)
C12Q 1/68 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/136 (2013.01)
Citation (search report)
See references of WO 2006065938A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006065938 A2 20060622; WO 2006065938 A3 20070208; AU 2005316532 A1 20060622; CA 2591918 A1 20060622; EP 1838872 A2 20071003
DOCDB simple family (application)
US 2005045317 W 20051215; AU 2005316532 A 20051215; CA 2591918 A 20051215; EP 05854102 A 20051215