Global Patent Index - EP 1838875 A4

EP 1838875 A4 20100825 - COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION USING SELF-PROTECTED OLIGONUCLEOTIDES

Title (en)

COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION USING SELF-PROTECTED OLIGONUCLEOTIDES

Title (de)

ZUSAMMENSETZUNGEN UND VERFAHREN ZUR MODULATION DER GENEXPRESSION UNTER VERWENDUNG SELBSTGESCHÜTZER OLIGONUKLEOTIDE

Title (fr)

COMPOSITIONS ET PROCEDES POUR LA MODULATION DE L'EXPRESSION GENIQUE PAR OLIGONUCLEOTIDES A AUTOPROTECTION

Publication

EP 1838875 A4 20100825 (EN)

Application

EP 05857262 A 20051230

Priority

  • US 2005047610 W 20051230
  • US 64058404 P 20041230

Abstract (en)

[origin: WO2006074108A2] The present invention is directed to novel nucleic acid molecules which include a region complementary to a target gene and one or more self-complementary regions, and the use of such nucleic acid molecules and compositions comprising the same to modulate gene expression and treat a variety of diseases and infections.

IPC 8 full level

C12Q 1/68 (2006.01); A01N 43/04 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12N 15/63 (2006.01); C12P 19/34 (2006.01)

CPC (source: EP US)

A61P 19/04 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 31/10 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 33/02 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C12N 15/111 (2013.01 - EP US); C12N 15/1135 (2013.01 - EP US); C12N 2310/11 (2013.01 - EP US); C12N 2310/111 (2013.01 - EP US); C12N 2310/14 (2013.01 - EP US); C12N 2310/53 (2013.01 - EP US); C12N 2320/51 (2013.01 - EP US)

Citation (search report)

  • [XI] WO 9412633 A1 19940609 - STIEFEL LABORATORIES [US], et al
  • [XYI] WO 9423026 A1 19941013 - GENSET SA [FR], et al
  • [XI] WO 0017346 A2 20000330 - RIBOZYME PHARM INC [US], et al
  • [XI] WO 9401550 A1 19940120 - HYBRIDON INC [US], et al
  • [XI] US 2002156261 A1 20021024 - MALVY CALUDE [FR], et al
  • [XI] ZHANG RUIWEN ET AL: "In vivo stability and disposition of a self-stabilized oligodeoxynucleotide phosphorothioate in rats", CLINICAL CHEMISTRY, vol. 41, no. 6 PART 1, 1995, pages 836 - 843, XP002589305, ISSN: 0009-9147
  • [XI] TANG J Y ET AL: "SELF-STABILIZED ANTISENSE OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES: PROPERTIES AND ANTI-HIV ACTIVITY", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 21, no. 11, 1 January 1993 (1993-01-01), pages 2729 - 2735, XP002030620, ISSN: 0305-1048
  • [XI] PODDEVIN B ET AL: "Improved anti-herpes simplex virus type 1 activity of a phosphodiester antisense oligonucleotide containing a 3'-terminal hairpin-like structure.", ANTISENSE RESEARCH AND DEVELOPMENT FALL 1994 LNKD- PUBMED:7849485, vol. 4, no. 3, October 1994 (1994-10-01), pages 147 - 154, XP002589147, ISSN: 1050-5261
  • [XI] HOSONO K ET AL: "PROPERTIES AND ANTI-HIV ACTIVITY OF HAIRPIN ANTISENSE OLIGONUCLEOTIDES CONTAINING 2'-METHOXYNUCLEOSIDES WITH BASE-PAIRINGIN THE STEM REGION AT THE 3'-END", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, BLACKWELL SCIENTIFIC PUBL., LONDON, GB, vol. 7, no. 2, 1 January 1996 (1996-01-01), pages 86 - 93, XP000877270, ISSN: 0956-3202
  • [Y] HIROTA Y ET AL: "P53 ANTISENSE OLIGONUCLEOTIDE INHIBITS GROWTH OF HUMAN COLON TUMOR AND NORMAL CELL LINES", JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 87, no. 7, 1 July 1996 (1996-07-01), pages 735 - 742, XP001062844, ISSN: 0910-5050
  • [Y] SKILLING JEFFREY S ET AL: "P53 Gene mutation analysis and antisense-mediated growth inhibition of human ovarian carcinoma cell lines", GYNECOLOGIC ONCOLOGY, vol. 60, no. 1, 1996, pages 72 - 80, XP002589148, ISSN: 0090-8258
  • [Y] FRIEDMAN KENNETH J ET AL: "Correction of aberrant splicing of the cystic fibrosis transmembrane conductance regulator (CFTR) gene by antisense oligonucleotides", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 51, 17 December 1999 (1999-12-17), pages 36193 - 36199, XP002589149, ISSN: 0021-9258
  • See references of WO 2006074108A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2006074108 A2 20060713; WO 2006074108 A3 20070412; BR PI0519690 A2 20090303; CN 101124339 A 20080213; EP 1838875 A2 20071003; EP 1838875 A4 20100825; JP 2008526213 A 20080724; MX 2007008065 A 20080304; US 2009005332 A1 20090101

DOCDB simple family (application)

US 2005047610 W 20051230; BR PI0519690 A 20051230; CN 200580048308 A 20051230; EP 05857262 A 20051230; JP 2007549691 A 20051230; MX 2007008065 A 20051230; US 81319005 A 20051230