Global Patent Index - EP 1843753 A2

EP 1843753 A2 2007-10-17 - COMPOSITIONS FOR FREEZE-DRYING PROTEINS

Title (en)

COMPOSITIONS FOR FREEZE-DRYING PROTEINS

Title (de)

ZUSAMMENSETZUNGEN FÜR GEFRIERGETROCKNETE PROTEINE

Title (fr)

COMPOSITIONS POUR LA LYOPHILISATION DE PROTEINES

Publication

EP 1843753 A2 (FR)

Application

EP 06709174 A

Priority

  • FR 2006000177 W
  • FR 0500791 A

Abstract (en)

[origin: FR2881139A1] A liquid composition (A) for lyophilization of proteins (I), previously diluted in (A), so as to stabilize (I) in the dry, lyophilized state and optionally also in the liquid state after rehydration of the lyophilizate, where (A) has a predominantly crystalline or amorphous structure when lyophilized, comprises a filler, stabilizer, buffer and optionally nonionic surfactant. A liquid composition (A) for lyophilization of proteins (I), previously diluted in (A), so as to stabilize (I) in the dry, lyophilized state and optionally also in the liquid state after rehydration of the lyophilizate, where (A) has a predominantly crystalline or amorphous structure when lyophilized, comprises about 40-60 g/l filler (II) with temperature of collapse (Tc) -18 to 0[deg]C; 10-20 g/l of a stabilizer (III); 10-20 mM buffer solution (IV) that does not crystallize when the composition is frozen and optionally 0.1-0.4 g/l of nonionic surfactant (V). In (A) the weight ratio (II):(III) is over 3:1 when the composition has a mainly crystalline structure when frozen; the weight ratio (III):(I) is over 1:1; (A) contains no excipients of animal origin, and Tc is -16 to -10[deg]C. Independent claims are also included for: (1) lyophilizing selected proteins (I) that includes dissolving them in (A); (2) preparing (I) stabilized in solution by rehydrating lyophilized products of method (1); (3) screening (A) for use in lyophilization of particular proteins; and (4) liquid compositions (A).

IPC 8 full level (invention and additional information)

A61K 9/19 (2006.01); A61K 38/00 (2006.01); A61K 47/02 (2006.01); A61K 47/10 (2006.01); A61K 47/18 (2006.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01); A61K 47/36 (2006.01); C12N 1/04 (2006.01)

CPC (invention and additional information)

A61K 9/19 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01); A61K 47/36 (2013.01)

Citation (search report)

See references of WO 2006079722A3

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

EPO simple patent family

FR 2881139 A1 20060728; EP 1843753 A2 20071017; WO 2006079722 A2 20060803; WO 2006079722 A3 20061019

INPADOC legal status


2010-03-17 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20090924

2009-06-17 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20090513

2008-04-30 [DAX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT (TO ANY COUNTRY) DELETED

2007-10-17 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20070618

2007-10-17 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR