EP 1843779 A2 20071017 - COMPOSITIONS CONTAINING THE ANTI-ANGIOGENIC PHSCN-PEPTIDE
Title (en)
COMPOSITIONS CONTAINING THE ANTI-ANGIOGENIC PHSCN-PEPTIDE
Title (de)
ZUSAMMENSETZUNGEN MIT ANTIANGIOGENEM PHSCN-PEPTID
Title (fr)
PRÉPARATIONS AMÉLIORÉES DE PEPTIDES ANTI-ANGIOGÉNIQUES
Publication
Application
Priority
- US 2006003461 W 20060201
- US 64839105 P 20050201
Abstract (en)
[origin: WO2006083906A2] Described herein are compositions/formulations of the Cys-containing anti-angiogenic peptide Pro-His-Ser-Cys-Asn (preferably in its capped form as Ac-PHSCN-NH2) or acid addition salts thereof or analogue thereof, that comprise at least one additional compound that stabilizes the peptide or analogue against spontaneous tandem dimerization or higher oligomerization. Preferred formulations include an acidic buffer such as citrate, glycine as an excipient and bulking agent. Optional additional components of the formulation are a reducing agent, a non-thiol biocompatible anti-oxidant, a lyoprotectant (typically one or more sugars, one or more amino acids, one or more methylamine, one or more lyotropic salts, and/or one or more polyols. Also provided is an article of manufacture or kit comprising the formulation in solution or in lyophilized form. A method of inhibiting angiogenesis in a subject, comprising administering to the subject the peptide in the above formulation is also disclosed.
IPC 8 full level
A61K 38/04 (2006.01)
CPC (source: EP KR US)
A61K 9/0019 (2013.01 - EP US); A61K 9/19 (2013.01 - EP); A61K 38/04 (2013.01 - EP KR); A61K 47/12 (2013.01 - EP); A61K 47/183 (2013.01 - EP US); A61K 47/20 (2013.01 - EP US); A61K 47/50 (2017.07 - KR); A61P 1/04 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP)
Citation (search report)
See references of WO 2006083906A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
WO 2006083906 A2 20060810; WO 2006083906 A3 20061005; AU 2006210895 A1 20060810; CA 2596255 A1 20060810; EP 1843779 A2 20071017; JP 2008528630 A 20080731; KR 20070100832 A 20071011
DOCDB simple family (application)
US 2006003461 W 20060201; AU 2006210895 A 20060201; CA 2596255 A 20060201; EP 06720021 A 20060201; JP 2007553365 A 20060201; KR 20077019974 A 20070831