Global Patent Index - EP 1843779 A2

EP 1843779 A2 2007-10-17 - COMPOSITIONS CONTAINING THE ANTI-ANGIOGENIC PHSCN-PEPTIDE

Title (en)

COMPOSITIONS CONTAINING THE ANTI-ANGIOGENIC PHSCN-PEPTIDE

Title (de)

ZUSAMMENSETZUNGEN MIT ANTIANGIOGENEM PHSCN-PEPTID

Title (fr)

PRÉPARATIONS AMÉLIORÉES DE PEPTIDES ANTI-ANGIOGÉNIQUES

Publication

EP 1843779 A2 (EN)

Application

EP 06720021 A

Priority

  • US 2006003461 W
  • US 64839105 P

Abstract (en)

[origin: WO2006083906A2] Described herein are compositions/formulations of the Cys-containing anti-angiogenic peptide Pro-His-Ser-Cys-Asn (preferably in its capped form as Ac-PHSCN-NH2) or acid addition salts thereof or analogue thereof, that comprise at least one additional compound that stabilizes the peptide or analogue against spontaneous tandem dimerization or higher oligomerization. Preferred formulations include an acidic buffer such as citrate, glycine as an excipient and bulking agent. Optional additional components of the formulation are a reducing agent, a non-thiol biocompatible anti-oxidant, a lyoprotectant (typically one or more sugars, one or more amino acids, one or more methylamine, one or more lyotropic salts, and/or one or more polyols. Also provided is an article of manufacture or kit comprising the formulation in solution or in lyophilized form. A method of inhibiting angiogenesis in a subject, comprising administering to the subject the peptide in the above formulation is also disclosed.

IPC 8 full level (invention and additional information)

A61K 38/04 (2006.01)

CPC (invention and additional information)

A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 38/04 (2013.01); A61K 47/12 (2013.01); A61K 47/183 (2013.01)

Citation (search report)

See references of WO 2006083906A3

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK YU

EPO simple patent family

WO 2006083906 A2 20060810; WO 2006083906 A3 20061005; AU 2006210895 A1 20060810; CA 2596255 A1 20060810; EP 1843779 A2 20071017; JP 2008528630 A 20080731; KR 20070100832 A 20071011

INPADOC legal status


2008-03-19 [RIN1] INVENTOR (CORRECTION)

- Inventor name: MAZAR, ANDREW, P

2008-03-19 [RIN1] INVENTOR (CORRECTION)

- Inventor name: HEIATI, HASHEM

2008-03-19 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SCHRIER, JAY

2008-03-19 [RIN1] INVENTOR (CORRECTION)

- Inventor name: LI, MING

2008-03-19 [RIN1] INVENTOR (CORRECTION)

- Inventor name: HARRIS, SCOTT

2007-12-12 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20071107

2007-10-17 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20070801

2007-10-17 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

2007-10-17 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Countries: AL BA HR MK YU