Global Patent Index - EP 1844015 A2

EP 1844015 A2 2007-10-17 - NOVEL HETEROCYCLIC OXIME DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Title (en)

NOVEL HETEROCYCLIC OXIME DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Title (de)

NEUE HETEROCYCLISCHE OXIMDERIVATE, HERSTELLUNGSVERFAHREN DAFÜR UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DAMIT

Title (fr)

NOUVEAUX DERIVES D'OXIMES HETEROCYCLIQUES, LEURS PROCEDE DE PREPARATION , LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT ET LEURS UTILISATION POUR LE TRAITEMENT DE L'OBESITE

Publication

EP 1844015 A2 (FR)

Application

EP 06709171 A

Priority

  • FR 2006000174 W
  • FR 0500842 A

Abstract (en)

[origin: FR2881137A1] Heterocyclic oxime derivatives (I), their enantiomers, diastereomers and their acid or basic addition salts are new. Heterocyclic oxime derivatives of formula (I), their enantiomers, diastereomers and their acid or basic addition salts are new. A : 1-6C alkyl (where CH 2 can be replaced by heteroatom (O or S)), NR a or a phenyl or naphthyl group; R aH or 1-6C alkyl; R 1>, R 2>, R, R1 : H, 1-6C ((hetero)aryl)alkyl, 2-6C ((hetero)aryl)alkenyl, 2-6C ((hetero)aryl)alkynyl, (hetero)aryl, 3-8C cycloalkyl-1-6C alkyl or polyhalo-1-6C alkyl; either R 3>, R 4>H, halo, R, OR or NRR1; or -C-R 3>-R 4>-C- : 5-6 membered ring (containing heteroatom (O, S or N); B 1>1-6C alkyl, 2-6C alkenyl (both optionally substituted by -CHR 5>R 6> or R 7>), -CHR 5>R 6> or R 7>; R 5>-C(=Z)-OR, -C(=Z)-NRR1, -N(R)-C(=Z)-R1 or -N(R)-C(=Z)-OR1; Z : O or S; R 6>(hetero)aryl, (hetero)aryl-1-6C alkyl, CN, tetrazole, OR, NRR1, -N(R)-C(=Z)-R1, -N(R)-C(=Z)-OR1 or -N(R)-C(=Z)-R; R 7>CN, tetrazole, -N(R)-C(=Z)-R1, -N(R)-C(=Z)-OR1 or -O-(CH 2) n-C(R 8>R 9>)-COOR; n : 1-6; and R 8>, R 9>H or 1-6C alkyl. Provided that both R 8> and R 9> are not simultaneously H. Provided that (1) the oxime R 1>-C(=N-OR 2>)- can be the Z or E configuration; (2) the aryl are phenyl, naphthyl or biphenyl, which can be partially hydrogenated; (3) the heteroaryl are 5-10 membered mono or bicylic aromatic, where the bicyclics can partially be hydrogenated, and containing 1-3 heteroatom (O, N or S); and (4) the (hetero)aryl are optionally substituted by 1-3 of 1-6C (polyhalo)alkyl, 1-6C alkoxy, OH, carboxy, 1-6C alkoxycarbonyl, 1-6C acyloxy, formyl, 1-6C acyl, aryl, NR bR c, amido, nitro, CN or halo, where R b, R c are H, 1-6C alkyl or (hetero)aryl. Independent claims are included for: (1) the preparations of (I); (2) a composition (X) comprising (I) an antioxidant agent. [Image] ACTIVITY : Antidiabetic; Antilipemic; Analgesic; Antianginal; Cardiant; Vasotropic; Cardiovascular-Gen.; Nephrotropic; Ophthalmological; Antipsoriatic; Gynecological; Osteopathic; Gastrointestinal-Gen.; Antiinflammatory; Antiarteriosclerotic; Anorectic; Anabolic; Eating-Disorders-Gen.; Neuroprotective; Cytostatic; Endocrine-Gen.; Neuroleptic. MECHANISM OF ACTION : Angiogenesis inhibitor.

IPC 8 full level (invention and additional information)

C07D 215/06 (2006.01); A61K 31/4709 (2006.01); A61P 3/04 (2006.01); C07D 215/58 (2006.01)

CPC (invention and additional information)

C07D 215/12 (2013.01)

Citation (search report)

See references of WO 2006079719A3

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK YU

EPO simple patent family

FR 2881137 A1 20060728; FR 2881137 B1 20070302; AR 052891 A1 20070411; AU 2006208812 A1 20060803; BR PI0607087 A2 20090804; CA 2596156 A1 20060803; CN 101133028 A 20080227; EA 200701477 A1 20080228; EP 1844015 A2 20071017; JP 2008528560 A 20080731; KR 20070103447 A 20071023; MA 29257 B1 20080201; MX 2007008995 A 20070918; NO 20074347 A 20070827; US 2009124656 A1 20090514; WO 2006079719 A2 20060803; WO 2006079719 A3 20060928; ZA 200706249 B 20081126

INPADOC legal status


2010-07-21 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20100115

2009-10-07 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20090904

2007-12-05 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: PARMENON, CECILE

2007-12-05 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: VIAUD-MASSUARD, MARIE-CLAUDE

2007-12-05 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: GUILLARD, JEROME

2007-12-05 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: DACQUET, CATHERINE

2007-12-05 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: KTORZA, ALAIN

2007-12-05 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: CAIGNARD, DANIEL-HENRI

2007-10-17 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20070712

2007-10-17 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

2007-10-17 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Countries: AL BA HR MK YU