EP 1844015 A2 20071017 - NOVEL HETEROCYCLIC OXIME DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
Title (en)
NOVEL HETEROCYCLIC OXIME DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
Title (de)
NEUE HETEROCYCLISCHE OXIMDERIVATE, HERSTELLUNGSVERFAHREN DAFÜR UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DAMIT
Title (fr)
NOUVEAUX DERIVES D'OXIMES HETEROCYCLIQUES, LEURS PROCEDE DE PREPARATION , LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT ET LEURS UTILISATION POUR LE TRAITEMENT DE L'OBESITE
Publication
Application
Priority
- FR 2006000174 W 20060126
- FR 0500842 A 20050127
Abstract (en)
[origin: FR2881137A1] Heterocyclic oxime derivatives (I), their enantiomers, diastereomers and their acid or basic addition salts are new. Heterocyclic oxime derivatives of formula (I), their enantiomers, diastereomers and their acid or basic addition salts are new. A : 1-6C alkyl (where CH 2 can be replaced by heteroatom (O or S)), NR a or a phenyl or naphthyl group; R aH or 1-6C alkyl; R 1>, R 2>, R, R1 : H, 1-6C ((hetero)aryl)alkyl, 2-6C ((hetero)aryl)alkenyl, 2-6C ((hetero)aryl)alkynyl, (hetero)aryl, 3-8C cycloalkyl-1-6C alkyl or polyhalo-1-6C alkyl; either R 3>, R 4>H, halo, R, OR or NRR1; or -C-R 3>-R 4>-C- : 5-6 membered ring (containing heteroatom (O, S or N); B 1>1-6C alkyl, 2-6C alkenyl (both optionally substituted by -CHR 5>R 6> or R 7>), -CHR 5>R 6> or R 7>; R 5>-C(=Z)-OR, -C(=Z)-NRR1, -N(R)-C(=Z)-R1 or -N(R)-C(=Z)-OR1; Z : O or S; R 6>(hetero)aryl, (hetero)aryl-1-6C alkyl, CN, tetrazole, OR, NRR1, -N(R)-C(=Z)-R1, -N(R)-C(=Z)-OR1 or -N(R)-C(=Z)-R; R 7>CN, tetrazole, -N(R)-C(=Z)-R1, -N(R)-C(=Z)-OR1 or -O-(CH 2) n-C(R 8>R 9>)-COOR; n : 1-6; and R 8>, R 9>H or 1-6C alkyl. Provided that both R 8> and R 9> are not simultaneously H. Provided that (1) the oxime R 1>-C(=N-OR 2>)- can be the Z or E configuration; (2) the aryl are phenyl, naphthyl or biphenyl, which can be partially hydrogenated; (3) the heteroaryl are 5-10 membered mono or bicylic aromatic, where the bicyclics can partially be hydrogenated, and containing 1-3 heteroatom (O, N or S); and (4) the (hetero)aryl are optionally substituted by 1-3 of 1-6C (polyhalo)alkyl, 1-6C alkoxy, OH, carboxy, 1-6C alkoxycarbonyl, 1-6C acyloxy, formyl, 1-6C acyl, aryl, NR bR c, amido, nitro, CN or halo, where R b, R c are H, 1-6C alkyl or (hetero)aryl. Independent claims are included for: (1) the preparations of (I); (2) a composition (X) comprising (I) an antioxidant agent. [Image] ACTIVITY : Antidiabetic; Antilipemic; Analgesic; Antianginal; Cardiant; Vasotropic; Cardiovascular-Gen.; Nephrotropic; Ophthalmological; Antipsoriatic; Gynecological; Osteopathic; Gastrointestinal-Gen.; Antiinflammatory; Antiarteriosclerotic; Anorectic; Anabolic; Eating-Disorders-Gen.; Neuroprotective; Cytostatic; Endocrine-Gen.; Neuroleptic. MECHANISM OF ACTION : Angiogenesis inhibitor.
IPC 8 full level
A61K 31/4709 (2006.01); A61P 3/04 (2006.01); C07D 215/06 (2006.01); C07D 215/58 (2006.01)
CPC (source: EP KR US)
A61K 9/20 (2013.01 - KR); A61K 31/4709 (2013.01 - KR); A61P 1/04 (2017.12 - EP); A61P 1/14 (2017.12 - EP); A61P 1/18 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/04 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 19/10 (2017.12 - EP); A61P 21/04 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 215/12 (2013.01 - EP KR US); C07D 215/58 (2013.01 - KR); C07B 2200/07 (2013.01 - KR)
Citation (search report)
See references of WO 2006079719A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
FR 2881137 A1 20060728; FR 2881137 B1 20070302; AR 052891 A1 20070411; AU 2006208812 A1 20060803; BR PI0607087 A2 20090804; CA 2596156 A1 20060803; CN 101133028 A 20080227; EA 200701477 A1 20080228; EP 1844015 A2 20071017; JP 2008528560 A 20080731; KR 20070103447 A 20071023; MA 29257 B1 20080201; MX 2007008995 A 20070918; NO 20074347 L 20070827; US 2009124656 A1 20090514; WO 2006079719 A2 20060803; WO 2006079719 A3 20060928; ZA 200706249 B 20081126
DOCDB simple family (application)
FR 0500842 A 20050127; AR P060100288 A 20060126; AU 2006208812 A 20060126; BR PI0607087 A 20060126; CA 2596156 A 20060126; CN 200680006477 A 20060126; EA 200701477 A 20060126; EP 06709171 A 20060126; FR 2006000174 W 20060126; JP 2007552679 A 20060126; KR 20077018500 A 20070813; MA 30148 A 20070817; MX 2007008995 A 20060126; NO 20074347 A 20070827; US 88310706 A 20060126; ZA 200706249 A 20060126