EP 1844066 A1 20071017 - MOTIF OF BECLIN PROTEIN WHICH INTERACTS WITH ANTI-APOPTOTIC MEMBERS OF THE FAMILY OF BCL-2 PROTEINS AND USE THEREOF
Title (en)
MOTIF OF BECLIN PROTEIN WHICH INTERACTS WITH ANTI-APOPTOTIC MEMBERS OF THE FAMILY OF BCL-2 PROTEINS AND USE THEREOF
Title (de)
MIT ANTI-APOPTOTISCHEN MITGLIEDERN DER BCL-2 PROTEIN-FAMILIE INTERAGIERENDES BECLIN-PROTEINMOTIV UND DESSEN VERWENDUNG
Title (fr)
MOTIF DE LA PROTEINE BECLIN INTERAGISSANT AVEC LES MEMBRES ANTI-APOPTOTIQUES DE LA FAMILLE DE PROTEINES BCL-2 ET UTILISATIONS
Publication
Application
Priority
- FR 2006000205 W 20060131
- FR 0500977 A 20050201
Abstract (en)
[origin: FR2881429A1] Identifying modulators of programmed cell death, comprising interacting the motif of beclin protein and anti-apoptotic member of Bcl-2, Bcl-XL/Bcl-W protein family and detecting the interaction optionally in presence of a compound to be tested, is new. Identifying modulators of programmed dead cells, comprising interacting the motif of beclin protein and anti-apoptotic member of Bcl-2, Bcl-XL/Bcl-W protein family and detecting the interaction optionally in presence of a compound, is new. The motif comprises Gly-Thr-Met-Glu-Asn-Leu-Ser-Arg-Arg-Leu-Lys-Val-Thr-Gly-Asp-Leu-Phe-Asp-Ile-Met-Ser-Gly-Gln-Thr-Asp-Val (SEQ ID NO. 1). Independent claims are included for: (1) a sequence of amino acids comprising (SEQ ID NO. 1); (2) a nucleic acid sequence (SEQ ID NO. 2) encoding the amino acid sequence of (1); (3) a nucleic acid sequence deduced from the genetic code of (SEQ ID NO. 1); (4) a recombinant vector comprising the nucleic acid sequence of (2); (5) a host cell transformed by the vector of (5); (6) a peptide comprising (SEQ ID NO. 1); (7) a peptide encoded by (SEQ ID NO. 2) or the nucleic acid sequence of (3); (5) a pharmaceutical composition comprising the peptide of (6) or (7). ACTIVITY : Cytostatic; Apoptotic. No biological data given. MECHANISM OF ACTION : None given.
IPC 8 full level
C07K 14/435 (2006.01); A61K 38/17 (2006.01); A61P 35/00 (2006.01); C12N 15/12 (2006.01); C12N 15/63 (2006.01); G01N 33/566 (2006.01); G01N 33/58 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 14/4747 (2013.01 - EP US); G01N 33/542 (2013.01 - EP US); G01N 33/57496 (2013.01 - EP US); G01N 2510/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
FR 2881429 A1 20060804; FR 2881429 B1 20070406; CA 2596672 A1 20060810; CN 101111518 A 20080123; EP 1844066 A1 20071017; JP 2008532486 A 20080821; US 2009099072 A1 20090416; US 7919233 B2 20110405; WO 2006082303 A1 20060810
DOCDB simple family (application)
FR 0500977 A 20050201; CA 2596672 A 20060131; CN 200680003806 A 20060131; EP 06709201 A 20060131; FR 2006000205 W 20060131; JP 2007553643 A 20060131; US 88343806 A 20060131