EP 1847603 A4 20090610 - METHOD FOR DETECTING p53 DYSFUNCTION, METHOD FOR MOLECULAR DIAGNOSIS OF CANCER AND METHOD FOR EVALUATING COMPOUND EFFECTIVE IN TREATING CANCER
Title (en)
METHOD FOR DETECTING p53 DYSFUNCTION, METHOD FOR MOLECULAR DIAGNOSIS OF CANCER AND METHOD FOR EVALUATING COMPOUND EFFECTIVE IN TREATING CANCER
Title (de)
VERFAHREN ZUM NACHWEIS EINER P53-FEHLFUNKTION, VERFAHREN ZUR MOLEKULAREN DIAGNOSE VON KREBS UND VERFAHREN ZUR BEURTEILUNG EINER BEI DER BEHANDLUNG VON KREBS WIRKSAMEN VERBINDUNG
Title (fr)
PROCEDE DE DETECTION D'UN DYSFONCTIONNEMENT DE P53, PROCEDE D'EVALUATION DES COMPOSES EFFICACES POUR LE TRAITEMENT DU CANCER
Publication
Application
Priority
- JP 2006301700 W 20060201
- JP 2005024905 A 20050201
Abstract (en)
[origin: EP1847603A1] Detection of p53 dysfunction or molecular diagnosis of cancer is carried out by a method comprising the steps of measuring the expression level of at least one gene selected from the group consisting of CARS, MOCOS, TNFRSF9, LOC56901 and GEF-H1 or a gene which is functionally equivalent to the gene in a test tissue or a test cell; comparing the expression level of the gene with that of a corresponding gene in a normal tissue or a normal cell; and determining whether or not the expression level of the gene in the test tissue or the test cell is significantly higher than that of the corresponding gene in the normal tissue or the normal cell based on the comparison result. According to the method for molecular diagnosis of the present invention, regardless of the presence of p53 mutation or without directly detecting p53 mutation, it becomes possible to detect p53 dysfunction or to diagnose cancer caused by p53 dysfunction.
IPC 8 full level
C12N 15/09 (2006.01); C12M 1/00 (2006.01); C12Q 1/68 (2006.01); G01N 33/53 (2006.01); G01N 37/00 (2006.01)
CPC (source: EP US)
C12Q 1/6886 (2013.01 - EP US); G01N 33/574 (2013.01 - EP US); G01N 33/57484 (2013.01 - EP US); C12Q 2600/106 (2013.01 - EP US); C12Q 2600/178 (2013.01 - EP US); G01N 2333/4748 (2013.01 - EP US); G01N 2800/52 (2013.01 - EP US)
Citation (search report)
- [X] US 2004241653 A1 20041202 - FEINSTEIN ELENA [IL], et al
- [X] US 2002120121 A1 20020829 - KORNELUK ROBERT G [CA], et al
- [A] WO 2004030615 A2 20040415 - GENENTECH INC [US], et al
- [X] SCIAN M J ET AL: "Modulation of gene expression by tumor-derived p53 mutants", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD.; US, vol. 64, no. 20, 15 October 2004 (2004-10-15), pages 7447 - 7454, XP002998014, ISSN: 0008-5472
- [X] OKADA T ET AL: "Gene expression profile linked to p53 status in hepatitis C virus-related hepatocellular carcinoma", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 555, no. 3, 18 December 2003 (2003-12-18), pages 583 - 590, XP004481054, ISSN: 0014-5793
- [X] KIM J E ET AL: "An elongation factor-associating domain is inserted into human cysteinyl-tRNA synthetase by alternative splicing", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 28, no. 15, 1 August 2000 (2000-08-01), pages 2866 - 2872, XP002998017, ISSN: 0305-1048
- See references of WO 2006082866A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
EP 1847603 A1 20071024; EP 1847603 A4 20090610; CA 2596687 A1 20060810; JP WO2006082866 A1 20080626; US 2009092971 A1 20090409; WO 2006082866 A1 20060810
DOCDB simple family (application)
EP 06712843 A 20060201; CA 2596687 A 20060201; JP 2006301700 W 20060201; JP 2007501601 A 20060201; US 88349606 A 20060201