Title (en)

METHOD FOR DETERMINING REDOX ACTIVITY AND SCREENING COMPOUNDS BASED ON REDOX ACTIVITY

Title (de)

VERFAHREN ZUR BESTIMMUNG EINER REDOX-AKTIVITÄT UND SCREENING-VERBINDUNGEN AUF BASIS EINER REDOX-AKTIVITÄT

Title (fr)

PROCEDE DESTINE A DETERMINER L'ACTIVITE OXYDOREDUCTRICE ET COMPOSES DE CRIBLAGE BASES SUR L'ACTIVITE OXYDOREDUCTRICE

Publication

EP 1848981 A2 20071031 (EN)

Application

EP 06734783 A 20060209

Priority

• US 2006004803 W 20060209
• US 65173005 P 20050209
• US 34093806 A 20060127

Abstract (en)

[origin: WO2006086670A2] A method for identifying the redox activity of a subject compound is disclosed. The method can be performed aerobically and can include forming a mixture comprising a free-radical precursor and a compound to be tested, and converting the free-radical precursor into a free-radical anion and a free-radical cation. After the free radical cation and the free radical anion have been formed, the relative redox activity of the subject compound may cause a difference in the rate of photo-bleaching of the mixture and/or the rate of superoxide generation. These differences can be quantified and used to identify the redox activity of the subject compound. This sensitive technique for measuring redox activity can be used to screen compounds for various biological applications. Drugs also can be developed based on the relationship between redox activity and biological activity for particular biological applications.

IPC 8 full level

G01N 21/00 (2006.01); G01N 21/27 (2006.01); G01N 21/77 (2006.01); G01N 31/22 (2006.01)

CPC (source: EP)

G01N 21/272 (2013.01); G01N 21/77 (2013.01); G01N 31/224 (2013.01); G01N 2021/6439 (2013.01)

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2006086670 A2 20060817; WO 2006086670 A3 20070111; EP 1848981 A2 20071031; EP 1848981 A4 20120118

DOCDB simple family (application)

US 2006004803 W 20060209; EP 06734783 A 20060209