EP 1850835 A1 20071107 - ORAL PHARMACEUTICAL FOR OF LOSARTAN
Title (en)
ORAL PHARMACEUTICAL FOR OF LOSARTAN
Title (de)
ORALE PHARMAZEUTISCHE FORM VON LOSARTAN
Title (fr)
FORME PHARMACEUTIQUE ORALE DE LOSARTAN
Publication
Application
Priority
- EP 2006060158 W 20060221
- FR 0550476 A 20050221
- FR 0503451 A 20050406
Abstract (en)
[origin: WO2006087394A1] The invention concerns oral pharmaceutical forms of losartan, as well as related treatments and delivery methods. The invention concerns the use, in an oral pharmaceutical form comprising losartan, of a coating or a matrix including said losartan and enabling said losartan to be released in controlled manner, such that said form administered to subjects results, whether the patients have eaten or not, in reducing the standard deviation among individuals of Cmax, thereby ensuring a very low variability of the efficacy and therapeutic safety of the pharmaceutical form, compared to a pharmaceutical form of losartan with immediate release administered to the same sample of subjects, at a similar dose. The invention also concerns an oral pharmaceutical form of losartan capable of being administered once a day, at least as efficient as the other forms taken once daily and than the forms taken twice daily. The invention is thus an oral pharmaceutical form with modified release of losartan comprising a plurality of micro-units of losartan (mean diameter: 20-1000 µm) enabling, after being taken, a plasmatic profile of the type as those shown in figure 10 to be obtained.
IPC 8 full level
A61K 9/54 (2006.01); A61K 9/26 (2006.01); A61K 31/417 (2006.01)
CPC (source: EP US)
A61K 9/5078 (2013.01 - EP US); A61K 9/5084 (2013.01 - EP US); A61K 31/417 (2013.01 - EP US); A61P 9/12 (2017.12 - EP); A61P 43/00 (2017.12 - EP); A61K 9/2081 (2013.01 - EP US); A61K 9/5073 (2013.01 - EP US)
Citation (search report)
See references of WO 2006087394A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006087394 A1 20060824; CA 2598410 A1 20060824; EP 1850835 A1 20071107; JP 2008530185 A 20080807; US 2009123536 A1 20090514
DOCDB simple family (application)
EP 2006060158 W 20060221; CA 2598410 A 20060221; EP 06708433 A 20060221; JP 2007555640 A 20060221; US 88453406 A 20060221