EP 1851858 B1 20160608 - SUBSTRATE RECOGNITION BY DIFFERENTIABLE HUMAN MESENCHYMAL STEM CELLS
Title (en)
SUBSTRATE RECOGNITION BY DIFFERENTIABLE HUMAN MESENCHYMAL STEM CELLS
Title (de)
SUBSTRATERKENNUNG MITTELS DIFFERENZIERBARER MENSCHLICHER MESENCHYMALER STAMMZELLEN
Title (fr)
RECONNAISSANCE DE SUBSTRAT PAR CELLULES SOUCHES MESENCHYMATEUSES HUMAINES DIFFERENCIABLES
Publication
Application
Priority
- US 2005043876 W 20051201
- US 63323304 P 20041203
Abstract (en)
[origin: US2006128012A1] The invention described herein provides a structure for growing isolated differentiable human mesenchymal cells, which includes a three-dimensional matrix of fibers. The matrix serves as an implantable scaffolding for delivery of differentiable human mesenchymal cells in tissue engineering. The invention further provides compositions that contain the three-dimensional matrix of fibers seeded with isolated differentiable human mesenchymal cells, wherein the matrix forms a supporting scaffold for growing the isolated differentiable human mesenchymal cells, and wherein the differentiable human mesenchymal cells differentiate into a mature cell phenotype. The invention further provides methods of preparing the implantable nanofiber matrix scaffolding seeded with differentiable human mesenchymal cells for use in tissue engineering.
IPC 8 full level
A61K 35/12 (2006.01); A61L 27/18 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/56 (2006.01); C12M 1/12 (2006.01); C12N 5/077 (2010.01); C12N 5/0775 (2010.01); D01D 5/00 (2006.01); H03L 7/093 (2006.01)
CPC (source: EP US)
A61L 27/18 (2013.01 - EP US); A61L 27/3633 (2013.01 - EP US); A61L 27/3821 (2013.01 - EP US); A61L 27/3852 (2013.01 - EP US); A61L 27/3895 (2013.01 - EP US); A61L 27/56 (2013.01 - EP US); C12M 25/14 (2013.01 - EP US); C12N 5/0654 (2013.01 - EP US); C12N 5/0655 (2013.01 - EP US); C12N 5/0663 (2013.01 - EP US); D01D 5/0038 (2013.01 - EP US); H03L 7/093 (2013.01 - EP US); A61K 2035/124 (2013.01 - EP US); C12N 2506/1346 (2013.01 - EP US); C12N 2533/40 (2013.01 - EP US)
Citation (examination)
- PITTENGER M F ET AL: "MULTILINEAGE POTENTIAL OF ADULT HUMAN MESENCHYMAL STEM CELLS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 284, no. 5411, 2 April 1999 (1999-04-02), pages 143 - 147, XP000867221, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.284.5411.143
- YOSHIMOTO H ET AL: "A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 24, no. 12, 1 May 2003 (2003-05-01), pages 2077 - 2082, XP004413511, ISSN: 0142-9612, DOI: 10.1016/S0142-9612(02)00635-X
- CHEN G ET AL: "Chondrogenic differentiation of human mesenchymal stem cells cultured in a cobweb-like biodegradable scaffold", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 322, no. 1, 10 September 2004 (2004-09-10), pages 50 - 55, XP004526699, ISSN: 0006-291X, DOI: 10.1016/J.BBRC.2004.07.071
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
US 2006128012 A1 20060615; CA 2596957 A1 20060629; CA 2596957 C 20150414; EP 1851858 A2 20071107; EP 1851858 A4 20100106; EP 1851858 B1 20160608; US 2010233807 A1 20100916; WO 2006068809 A2 20060629; WO 2006068809 A3 20090409
DOCDB simple family (application)
US 29170105 A 20051201; CA 2596957 A 20051201; EP 05852938 A 20051201; US 2005043876 W 20051201; US 76375510 A 20100420