EP 1856104 A1 20071121 - PROCESSES AND COMPOUNDS FOR THE PREPARATION OF SUBSTITUTED NAPHTHYLINDOLE DERIVATIVES
Title (en)
PROCESSES AND COMPOUNDS FOR THE PREPARATION OF SUBSTITUTED NAPHTHYLINDOLE DERIVATIVES
Title (de)
VERFAHREN UND VERBINDUNGEN ZUR HERSTELLUNG SUBSTITUIERTER NAPHTHYLINDOL-DERIVATE
Title (fr)
PROCESSUS ET COMPOSES POUR LA PREPARATION DE DERIVES DE NAPHTHYLINDOLE SUBSTITUES
Publication
Application
Priority
- US 2006002996 W 20060125
- US 64761805 P 20050127
Abstract (en)
[origin: WO2006081455A1] The present invention provides processes for the preparation of substituted naphthyl indole derivatives of formula (I) that can be used as inhibitors of plasminogen activator inhibitor- 1 (PAI-I) . In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyl tetrazole with a substituted naphthol.
IPC 8 full level
A61K 31/41 (2006.01); A61P 7/02 (2006.01); C07D 403/12 (2006.01)
CPC (source: EP KR US)
A61K 31/41 (2013.01 - KR); A61P 7/02 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07C 45/00 (2013.01 - EP US); C07C 45/004 (2013.01 - EP US); C07C 49/84 (2013.01 - EP US); C07D 403/12 (2013.01 - EP KR US)
Citation (search report)
See references of WO 2006081455A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006081455 A1 20060803; AR 053437 A1 20070509; AU 2006208021 A1 20060803; BR PI0606871 A2 20090721; CA 2595376 A1 20060803; CN 101111491 A 20080123; CR 9215 A 20071123; EP 1856104 A1 20071121; GT 200600032 A 20061114; HN 2006003347 A 20110330; IL 183712 A0 20070920; JP 2008528618 A 20080731; KR 20070103744 A 20071024; MX 2007008952 A 20070918; NI 200700188 A 20080509; NO 20072879 L 20070626; PE 20061200 A1 20061219; RU 2007121255 A 20090310; TW 200637850 A 20061101; US 2006183917 A1 20060817; US 2008071091 A1 20080320; US 7323483 B2 20080129; ZA 200706203 B 20091230
DOCDB simple family (application)
US 2006002996 W 20060125; AR P060100283 A 20060126; AU 2006208021 A 20060125; BR PI0606871 A 20060125; CA 2595376 A 20060125; CN 200680003314 A 20060125; CR 9215 A 20070628; EP 06719721 A 20060125; GT 200600032 A 20060126; HN 2006003347 A 20060130; IL 18371207 A 20070606; JP 2007553280 A 20060125; KR 20077017498 A 20070727; MX 2007008952 A 20060125; NI 200700188 A 20070727; NO 20072879 A 20070606; PE 2006000111 A 20060126; RU 2007121255 A 20060125; TW 95102979 A 20060126; US 33980206 A 20060125; US 94610907 A 20071128; ZA 200706203 A 20070726