EP 1856247 A2 20071121 - REGULATION OF AUTOPHAGY AND CELL SURVIVAL
Title (en)
REGULATION OF AUTOPHAGY AND CELL SURVIVAL
Title (de)
REGULIERUNG VON AUTOPHAGIE UND ZELLÜBERLEBEN
Title (fr)
RÉGULATION DE L'AUTOPHAGIE ET DE LA SURVIE CELLULAIRE
Publication
Application
Priority
- US 2006001831 W 20060119
- US 64541905 P 20050119
Abstract (en)
[origin: WO2006078774A2] Methods of treating an individual who has been identified as having glycolysis dependent cancer are disclosed. The methods comprise the step of: administering to suc an individual a combination of an anti-cancer composition that renders the cancer incapable of glycolysis and an autophagy inhibitor. Pharmaceutical compositions and kits comprising that renders the cancer incapable of glycolysis and an autophagy inhibit are also disclosed. Methods of treating an individual who has a disease characterized b cell degeneration and cell death due to autophagy are disclosed. The methods comprise administering to the individual a permeable form of a metabolic substrate that can be oxidized in the tricarboxylic acid cycle to produce NADH. Methods for identifying an autophagy inhibitor comprising performing a test assay using an apopto sis-resistant cell are disclosed.
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/4706 (2006.01); A61K 31/675 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61K 31/00 (2013.01 - EP US); A61K 31/4706 (2013.01 - EP US); A61K 31/675 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 35/00 (2017.12 - EP); C12Q 1/26 (2013.01 - EP US); G01N 33/574 (2013.01 - EP US); G01N 2500/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
WO 2006078774 A2 20060727; WO 2006078774 A3 20080605; AU 2006206478 A1 20060727; AU 2006206478 B2 20120412; CA 2595156 A1 20060727; EP 1856247 A2 20071121; EP 1856247 A4 20110105; EP 1856247 B1 20160504; US 2008269259 A1 20081030; US 2018030502 A1 20180201
DOCDB simple family (application)
US 2006001831 W 20060119; AU 2006206478 A 20060119; CA 2595156 A 20060119; EP 06718839 A 20060119; US 201715447097 A 20170301; US 81436506 A 20060119