EP 1856522 A1 20071121 - ASSAYS FOR AGENTS WITH SELECTIVE CYTOTOXICTY TO HDAC RESISTANT CELL LINES
Title (en)
ASSAYS FOR AGENTS WITH SELECTIVE CYTOTOXICTY TO HDAC RESISTANT CELL LINES
Title (de)
TESTS FÜR AGENTIEN MIT SELEKTIVER ZYTOTOXIZITÄT GEGENÜBER HDAC-RESISTENTEN ZELLINIEN
Title (fr)
DOSAGES D'AGENTS AYANT UNE CYTOTOXICITE SELECTIVE ENVERS LES LIGNEES CELLULAIRES HDAC-RESISTANTES
Publication
Application
Priority
- GB 2006000425 W 20060206
- US 65014105 P 20050207
Abstract (en)
[origin: WO2006082448A1] This invention relates to a method of identifying and/or obtaining an agent which is selectively cytotoxic to histone deacetylase inhibitor (HDACi) resistant cells, said method comprising the steps of: a) incubating HDACi resistant cells and HDACi sensitive cells with a test agent, b) determining the cytotoxicity of the test agent for said HDACi resistant cells and the cytotoxicity of the test agent for said HDACi sensitive cells, wherein an increase in cytoxicity of the test agent for said HDACi resistant cells relative to said HDACi sensitive cells is indicative that the test agent is an agent which is selectively cytotoxic to HDACi resistant cells. The invention is based on the recognition that cells which are resistant to inhibitors of histone deacetylases (HDACis) such as PXD101 are hypersensitized to certain anti-cancer agents.
IPC 8 full level
G01N 33/50 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 43/00 (2017.12); G01N 33/5011 (2013.01)
Citation (search report)
See references of WO 2006082448A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006082448 A1 20060810; AU 2006210994 A1 20060810; CA 2596405 A1 20060810; EP 1856522 A1 20071121; JP 2008529487 A 20080807
DOCDB simple family (application)
GB 2006000425 W 20060206; AU 2006210994 A 20060206; CA 2596405 A 20060206; EP 06709669 A 20060206; JP 2007553709 A 20060206