EP 1858509 A4 20090318 - NOVEL CATHEPSIN C INHIBITORS AND THEIR USE
Title (en)
NOVEL CATHEPSIN C INHIBITORS AND THEIR USE
Title (de)
NEUE CATHEPSIN-C-HEMMER UND IHRE VERWENDUNG
Title (fr)
NOUVEAUX INHIBITEURS DE CATHEPSINE C ET LEUR UTILISATION
Publication
Application
Priority
- US 2006007162 W 20060301
- US 65789705 P 20050302
Abstract (en)
[origin: WO2006094003A1] The invention is directed to novel cathepsin C inhibitors and their use in the treatment of diseases mediated by the cathepsin C enzyme. Specifically, the invention is directed to compounds according to Formula (I): wherein X and n are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are cathepsin C inhibitors and can be used in the treatment of diseases mediated by the cathepsin C enzyme, such as COPD. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting cathepsin C and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
IPC 8 full level
A61K 31/415 (2006.01); A61P 11/00 (2006.01); C07D 231/04 (2006.01)
CPC (source: EP)
A61P 11/00 (2017.12); A61P 43/00 (2017.12); C07D 231/04 (2013.01)
Citation (search report)
- [Y] WO 2005000800 A1 20050106 - MERCK FROSST CANADA INC [CA], et al
- [A] WO 2004106289 A1 20041209 - COMBIO AS [DK], et al
- [A] WO 2004110988 A1 20041223 - COMBIO AS [DK], et al
- [PY] DEATON D N ET AL: "Novel and potent cyclic cyanamide-based cathepsin K inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 15, no. 7, 1 April 2005 (2005-04-01), pages 1815 - 1819, XP025313507, ISSN: 0960-894X, [retrieved on 20050401]
- [Y] RYDZEWSKI ROBERT M ET AL: "Peptidic 1-cyanopyrrolidines: Synthesis and SAR of a series of potent, selective cathepsin inhibitors", BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 10, no. 10, October 2002 (2002-10-01), pages 3277 - 3284, XP002512387, ISSN: 0968-0896
- [T] KIM S H ET AL: "Effect of novel N-cyano-tetrahydro-pyridazine compounds, a class of cathepsin K inhibitors, on the bone resorptive activity of mature osteoclasts", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 18, no. 14, 15 July 2008 (2008-07-15), pages 3988 - 3991, XP022852880, ISSN: 0960-894X, [retrieved on 20080610]
- See references of WO 2006094003A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
HR
DOCDB simple family (publication)
WO 2006094003 A1 20060908; EP 1858509 A1 20071128; EP 1858509 A4 20090318; JP 2008531706 A 20080814
DOCDB simple family (application)
US 2006007162 W 20060301; EP 06736473 A 20060301; JP 2007558151 A 20060301