EP 1861407 A1 20071205 - THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS
Title (en)
THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS
Title (de)
THIENOPYRIDINONDERIVATE ALS HEMMER DES MAKROPHAGENMIGRATIONSHEMMFAKTORS
Title (fr)
DERIVES DE THIENOPYRIDINONE UTILISES EN TANT QU'INHIBITEURS DU FACTEUR D'INHIBITION DE LA MIGRATION DES MACROPHAGES
Publication
Application
Priority
- US 2006009932 W 20060320
- US 66523605 P 20050324
- US 73365705 P 20051104
Abstract (en)
[origin: WO2006102191A1] Inhibitors of macrophage migration inhibitory factor having a thienopyridinone backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with macrophage migration inhibitory factor activity. The inhibitors of macrophage migration inhibitory factor have the following structures formula (I), (II), (III) including forms such as stereoisomers, free forms, pharmaceutically acceptable salts or esters thereof, solvates, or combinations of such forms, wherein n, R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, X, and Y are as defined herein. Compositions comprising an inhibitor of macrophage migration inhibitory factor in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
IPC 8 full level
C07D 495/04 (2006.01); A61K 31/429 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61P 1/04 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 495/04 (2013.01 - EP US); C07D 498/02 (2013.01 - EP US)
Citation (search report)
See references of WO 2006102191A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006102191 A1 20060928; AU 2006227297 A1 20060928; BR PI0609382 A2 20100330; CA 2600175 A1 20060320; EP 1861407 A1 20071205; JP 2008534502 A 20080828; US 2006229314 A1 20061012; US 2007179149 A1 20070802; US 7365200 B2 20080429
DOCDB simple family (application)
US 2006009932 W 20060320; AU 2006227297 A 20060320; BR PI0609382 A 20060320; CA 2600175 A 20060320; EP 06748457 A 20060320; JP 2008503061 A 20060320; US 38563006 A 20060320; US 68759807 A 20070316