EP 1863939 A2 20071212 - BIOMARKERS FOR EFFICACY OF ALISKIREN AS A HYPERTENSIVE AGENT
Title (en)
BIOMARKERS FOR EFFICACY OF ALISKIREN AS A HYPERTENSIVE AGENT
Title (de)
BIOMARKER FÜR DIE WIRKSAMKEIT VON ALISKIREN ALS BLUTDRUCKSTEIGERNDES MITTEL
Title (fr)
BIO-MARQUEURS POUR L'ÉVALUATION DE L'EFFICACITÉ DE L'ALISKIRÈNE EN TANT QU'AGENT HYPERTENSIF
Publication
Application
Priority
- US 2006009913 W 20060320
- US 66424805 P 20050322
- US 74240105 P 20051205
Abstract (en)
[origin: RU2408363C2] FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to medicine, particularly to therapy and pharmacology, particularly to pharmacogenetic analysis, and concerns detecting genetic polymorphisms being efficacy markers of aliskiren as an antihypertensive agent. Aliskiren is used for preparing a drug for treating hypertension, for reducing mean derived systolic pressure and for reducing diastolic pressure. And aliskiren therapy is applied in a group of patients specified by genetic polymorphisms in biomarker genes where the aliskiren efficacy is indicated by genetic polymorphisms - SNP_4769 as specified in SEQ ID NO:1 in an angiotesin-converting enzyme (ACE) gene, SNP1445 as specified in SEQ ID NO:2 in an angiotensin II receptor type 2 (AGTR2) gene, and SNP_4795 as specified in SEQ ID NO:3 in an AGTR2 gene . ^ EFFECT: invention provides a method for determining sensitivity of a hypertensive individual to the aliskiren therapy, and application of a gene product of a gene specified in a group including the angiotesin-converting enzyme (ACE) gene and angiotensin II receptor type 2 (AGTR2) gene as a drug target. ^ 6 cl, 1 dwg, 7 tbl, 2 ex
IPC 8 full level
Citation (search report)
See references of WO 2006102177A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
EP 1863939 A2 20071212; RU 2007138882 A 20090427; RU 2408363 C2 20110110
DOCDB simple family (application)
EP 06748451 A 20060320; RU 2007138882 A 20060320