EP 1865945 A1 20071219 - COMBINATION THERAPY FOR ENDOTHELIAL DYSFUNCTION, ANGINA AND DIABETES
Title (en)
COMBINATION THERAPY FOR ENDOTHELIAL DYSFUNCTION, ANGINA AND DIABETES
Title (de)
KOMBINATIONSTHERAPIE BEI ENDOTHEL-DYSFUNKTION, ANGINA UND DIABETES
Title (fr)
COMBINAISON DE TRAITEMENT POUR LES TROUBLES ENDOTHELIAUX, L'ANGINE ET LE DIABETE
Publication
Application
Priority
- US 2006008801 W 20060310
- US 66062505 P 20050311
- US 67511805 P 20050427
Abstract (en)
[origin: US2006205727A1] The combination of a HMG CoA reductase inhibitor like a statin, such as simvastatin, with a pFox inhibitor such as trimetazidine ("Simetazidine") is particularly advantageous for treatment of end-stage complications, such as acute coronary syndrome (ACS) and chronic angina, especially in type II diabetics. The combination therapy is also useful in the treatment and/or prevention of chronic heart failure (CHF) and peripheral arterial disease (PAD). The combination of a nitric oxide (NO) mechanism with increased NO production with pFox inhibition simultaneously treats both the effect and the cause of angina. One or more oral hypoglycemic compounds (biguanides, insulin sensitizers, such as thiazolidinediones, alpha-glucosidase inhibitors, insulin secretagogues, and dipeptidyl peptidase IV inhibitors), protein kinase C (PKC) inhibitors, and acetyl-CoA carboxylase inhibitors can also be used in combination with the HMG CoA reductase inhibitors and/or pFox inhibitors, especially in type II diabetics, to control glucose levels and treat endothelial dysfunction. The drugs can be given in combination (e.g. a single tablet) or in separate dosage forms, administered simultaneously or sequentially. In the preferred form the statin is given in a dose of between 5 and 80 mg/day in two separate doses, and the pFox inhibitor is administered in a sustained or extended dosage formulation at a dose of 20 mg three times a day or 35 mg two times a day. The dose of the oral hypoglycemic, PKC inhibitor, or acetyl-CoA carboxylase inhibitor varies with the type of drug used.
IPC 8 full level
A61K 31/40 (2006.01); A61K 31/4458 (2006.01); A61K 31/495 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01)
CPC (source: EP US)
A61K 31/22 (2013.01 - EP US); A61K 31/366 (2013.01 - EP US); A61K 31/40 (2013.01 - EP US); A61K 31/401 (2013.01 - EP US); A61K 31/4458 (2013.01 - EP US); A61K 31/495 (2013.01 - EP US); A61K 31/537 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/02 (2017.12 - EP); A61P 9/04 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
C-Set (source: EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
US 2006205727 A1 20060914; AU 2006223212 A1 20060921; EP 1865945 A1 20071219; EP 1865945 A4 20080521; JP 2008533044 A 20080821; WO 2006099244 A1 20060921
DOCDB simple family (application)
US 37365806 A 20060310; AU 2006223212 A 20060310; EP 06737931 A 20060310; JP 2008501018 A 20060310; US 2006008801 W 20060310