Global Patent Index - EP 1865945 A4

EP 1865945 A4 20080521 - COMBINATION THERAPY FOR ENDOTHELIAL DYSFUNCTION, ANGINA AND DIABETES

Title (en)

COMBINATION THERAPY FOR ENDOTHELIAL DYSFUNCTION, ANGINA AND DIABETES

Title (de)

KOMBINATIONSTHERAPIE BEI ENDOTHEL-DYSFUNKTION, ANGINA UND DIABETES

Title (fr)

COMBINAISON DE TRAITEMENT POUR LES TROUBLES ENDOTHELIAUX, L'ANGINE ET LE DIABETE

Publication

EP 1865945 A4 20080521 (EN)

Application

EP 06737931 A 20060310

Priority

  • US 2006008801 W 20060310
  • US 66062505 P 20050311
  • US 67511805 P 20050427

Abstract (en)

[origin: US2006205727A1] The combination of a HMG CoA reductase inhibitor like a statin, such as simvastatin, with a pFox inhibitor such as trimetazidine ("Simetazidine") is particularly advantageous for treatment of end-stage complications, such as acute coronary syndrome (ACS) and chronic angina, especially in type II diabetics. The combination therapy is also useful in the treatment and/or prevention of chronic heart failure (CHF) and peripheral arterial disease (PAD). The combination of a nitric oxide (NO) mechanism with increased NO production with pFox inhibition simultaneously treats both the effect and the cause of angina. One or more oral hypoglycemic compounds (biguanides, insulin sensitizers, such as thiazolidinediones, alpha-glucosidase inhibitors, insulin secretagogues, and dipeptidyl peptidase IV inhibitors), protein kinase C (PKC) inhibitors, and acetyl-CoA carboxylase inhibitors can also be used in combination with the HMG CoA reductase inhibitors and/or pFox inhibitors, especially in type II diabetics, to control glucose levels and treat endothelial dysfunction. The drugs can be given in combination (e.g. a single tablet) or in separate dosage forms, administered simultaneously or sequentially. In the preferred form the statin is given in a dose of between 5 and 80 mg/day in two separate doses, and the pFox inhibitor is administered in a sustained or extended dosage formulation at a dose of 20 mg three times a day or 35 mg two times a day. The dose of the oral hypoglycemic, PKC inhibitor, or acetyl-CoA carboxylase inhibitor varies with the type of drug used.

IPC 8 full level

A61K 31/40 (2006.01); A61K 31/4458 (2006.01); A61K 31/495 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01)

CPC (source: EP US)

A61K 31/22 (2013.01 - EP US); A61K 31/366 (2013.01 - EP US); A61K 31/40 (2013.01 - EP US); A61K 31/401 (2013.01 - EP US); A61K 31/4458 (2013.01 - EP US); A61K 31/495 (2013.01 - EP US); A61K 31/537 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/02 (2017.12 - EP); A61P 9/04 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 43/00 (2017.12 - EP)

Citation (search report)

  • [XY] WO 0128499 A2 20010426 - NITROSYSTEMS INC [US]
  • [Y] DE 19913528 A1 20000629 - SANOL ARZNEI SCHWARZ GMBH [DE]
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  • [Y] WO 9210188 A1 19920625 - SMITHKLINE BEECHAM PLC [GB]
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  • [Y] US H1286 H 19940201 - EISMAN MARTIN [US], et al
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  • [Y] WO 9947123 A1 19990923 - BRISTOL MYERS SQUIBB CO [US]
  • [Y] WO 9513063 A1 19950518 - MERCK & CO INC [US], et al
  • [Y] EP 0407780 A2 19910116 - SYNTEX PHARMA LTD [GB]
  • [Y] WO 0160348 A2 20010823 - CV THERAPEUTICS INC [US], et al
  • [Y] US 2004192702 A1 20040930 - ZABLOCKI JEFF [US], et al
  • [Y] WO 0178747 A1 20011025 - BAYER AG [DE], et al
  • [Y] RUPP H ET AL: "THE USE OF PARTIAL FATTY ACID OXIDATION INHIBITORS FOR METABOLIC THERAPY OF ANGINA PECTORIS AND HEART FAILURE", HERZ, URBAN UND VOGEL, MUENCHEN, DE, vol. 27, no. 7, November 2002 (2002-11-01), pages 621 - 636, XP001204997, ISSN: 0340-9937
  • [Y] LEE L ET AL: "AUGMENTATION OF GLUCOSE METABOLISM WITH PERHEXILINE IMPROVES MAXIMAL OXYGEN CONSUMPTION AND QUALITY OF LIFE IN PATIENTS WITH NONISCHAEMIC DILATED CARDIOMYOPATHY", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER, NEW YORK, NY, US, vol. 43, no. 5, SUPPL A, 3 March 2003 (2003-03-03), pages 190A, XP001204996, ISSN: 0735-1097
  • [Y] CHEN YINGJIE ET AL: "Nitric oxide modulates myocardial oxygen consumption in the failing heart", CIRCULATION, vol. 106, no. 2, 9 July 2002 (2002-07-09), pages 273 - 279, XP002471707, ISSN: 0009-7322
  • [Y] SETTY S ET AL: "Nitric oxide contributes to oxygen demand-supply balance in hypoperfused right ventricle", CARDIOVASCULAR RESEARCH, XX, XX, vol. 64, no. 3, 1 December 2004 (2004-12-01), pages 431 - 436, XP004645760, ISSN: 0008-6363
  • [X] SYRKIN A L ET AL: "[Antiischemic efficacy of trimetazidine in patients with intermittent claudication and effort angina]", KARDIOLOGIIA 2003, vol. 43, no. 7, 2003, pages 49 - 52, XP009096875, ISSN: 0022-9040
  • See references of WO 2006099244A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

US 2006205727 A1 20060914; AU 2006223212 A1 20060921; EP 1865945 A1 20071219; EP 1865945 A4 20080521; JP 2008533044 A 20080821; WO 2006099244 A1 20060921

DOCDB simple family (application)

US 37365806 A 20060310; AU 2006223212 A 20060310; EP 06737931 A 20060310; JP 2008501018 A 20060310; US 2006008801 W 20060310