EP 1866411 A1 20071219 - IMPROVED PROLIFERATIVE CAPACITY USING CELL-CELL FUSION GENERATED HYBRIDS
Title (en)
IMPROVED PROLIFERATIVE CAPACITY USING CELL-CELL FUSION GENERATED HYBRIDS
Title (de)
VERBESSERTES PROLIFERATIONSVERMOGEN UNTER VERWENDUNG DURCH ZELL-ZELL-FUSION ERZEUGTER HYBRIDE
Title (fr)
CAPACITÉ PROLIFÉRATIVE AMÉLIORÉE À L'AIDE D'HYBRIDES GÉNÉRÉS PAR FUSION CELLULE-CELLULE
Publication
Application
Priority
- SE 2006000363 W 20060322
- SE 0500711 A 20050322
Abstract (en)
[origin: WO2006101444A1] The current invention concerns improving cell proliferative potential and prolonging the expected lifespan of differentiated, as well as non-differentiated cells. This is achieved through the generation of activated cells which in turn stimulate the growth of cells displaying non-dividing/senescent cell phenotypes. Activated cells are induced using cells or derivatives of the F7 cell line, and may be intra- and/or inter-species cell hybrids generated by cell-cell fusion or can be achieved using conditioned media from F7 cell culturing. Resulting activated cells have superior proliferation potential compared to the non-activated parental cell types and can be characterised by chromosomal heteroploidy/aneuploidy . The improved growth properties of the activated cells generated can be utilized directly in facilitating the clinical and medical treatment of diseases in humans and other mammals and for the repair of damaged tissues/organs, or can be utilized indirectly to provide media and/or factors with unique growth promoting and/or sustaining properties. Generation of hybrid or activated cells in accordance with the present invention provide an alternative to conventional embryonic and adult stem cells, and circumvent the need for the specialised and costly cell culture techniques required in current stem cell applications.
IPC 8 full level
C12N 5/22 (2006.01); A61L 27/38 (2006.01)
CPC (source: EP)
C12N 5/166 (2013.01); C12N 2510/04 (2013.01)
Citation (search report)
See references of WO 2006101444A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
WO 2006101444 A1 20060928; CA 2602136 A1 20060928; EP 1866411 A1 20071219
DOCDB simple family (application)
SE 2006000363 W 20060322; CA 2602136 A 20060322; EP 06717046 A 20060322