EP 1869019 A1 20071226 - BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS
Title (en)
BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS
Title (de)
BICYCLISCHE [3.1.0]-HETEROARYLAMIDE ALS TYP-I-GLYCINTRANSPORTINHIBITOREN
Title (fr)
HETEROARYLAMIDES BICYCLIQUES [3.1.0] COMME INHIBITEURS DE TRANSPORT DE LA GLYCINE
Publication
Application
Priority
- IB 2006000947 W 20060327
- US 66947205 P 20050408
Abstract (en)
[origin: WO2006106425A1] The present invention relates to a series of substituted bicyclic[3.1.0] heteroaryl amides of the Formula I, wherein A, Q, X, Y, Z and R<SUB>1</SUB>-R<SUB>5</SUB> groups are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.
IPC 8 full level
C07D 403/12 (2006.01); A61K 31/4178 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01); A61P 25/00 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP KR NO US)
A61K 31/4178 (2013.01 - KR NO); A61P 25/00 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 401/12 (2013.01 - EP KR NO US); C07D 403/12 (2013.01 - EP KR NO US); C07D 403/14 (2013.01 - EP US); C07D 405/14 (2013.01 - EP US); C07D 413/12 (2013.01 - EP NO US); C07D 413/14 (2013.01 - EP US); C07D 417/12 (2013.01 - EP NO US)
Citation (search report)
See references of WO 2006106425A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
WO 2006106425 A1 20061012; AP 2007004198 A0 20071031; AR 056307 A1 20071003; AU 2006231917 A1 20061012; AU 2006231917 B2 20110728; BR PI0608148 A2 20091110; CA 2603939 A1 20061012; CA 2603939 C 20130827; CN 101189228 A 20080528; CR 9493 A 20071204; DK 1869019 T3 20141006; DO P2006000078 A 20061015; EA 014311 B1 20101029; EA 200701902 A1 20080428; EP 1869019 A1 20071226; EP 1869019 B1 20140827; ES 2520015 T3 20141111; GE P20105053 B 20100726; GT 200600136 A 20061107; HN 2006013804 A 20091030; IL 186409 A0 20080120; IL 186409 A 20120731; JP 2008534671 A 20080828; JP 4193949 B2 20081210; KR 100969402 B1 20100714; KR 20070120582 A 20071224; MA 29672 B1 20080801; MX 2007012463 A 20071107; NL 1031539 A1 20061010; NL 1031539 C2 20070410; NO 20074993 L 20071102; NO 339422 B1 20161212; NZ 563238 A 20110128; PE 20061400 A1 20070115; TN SN07380 A1 20090317; TW 200719890 A 20070601; UA 88518 C2 20091026; US 2006229455 A1 20061012; US 2010324020 A1 20101223; US 8124639 B2 20120228; UY 29456 A1 20061130; ZA 200708481 B 20100526
DOCDB simple family (application)
IB 2006000947 W 20060327; AP 2007004198 A 20060327; AR P060101362 A 20060406; AU 2006231917 A 20060327; BR PI0608148 A 20060327; CA 2603939 A 20060327; CN 200680019890 A 20060327; CR 9493 A 20071101; DK 06727516 T 20060327; DO 2006000078 A 20060331; EA 200701902 A 20060327; EP 06727516 A 20060327; ES 06727516 T 20060327; GE AP2006010309 A 20060327; GT 200600136 A 20060406; HN 2006013804 A 20060406; IL 18640907 A 20071007; JP 2008504868 A 20060327; KR 20077025888 A 20060327; MA 30281 A 20071008; MX 2007012463 A 20060327; NL 1031539 A 20060407; NO 20074993 A 20071003; NZ 56323806 A 20060327; PE 2006000374 A 20060406; TN SN07380 A 20071008; TW 95112431 A 20060407; UA A200711021 A 20060327; US 39907106 A 20060406; US 87092810 A 20100830; UY 29456 A 20060405; ZA 200708481 A 20071004