EP 1871787 A2 20080102 - POLYMYXIN B ANALOGS FOR LPS DETOXIFICATION
Title (en)
POLYMYXIN B ANALOGS FOR LPS DETOXIFICATION
Title (de)
POLYMYXIN-B-ANALOGA ZUR LPS-DETOXIFIZIERUNG
Title (fr)
ANALOGUES B DE POLYMYXINE DESTINES A LA DETOXIFICATION LPS
Publication
Application
Priority
- EP 2006003237 W 20060410
- EP 05300270 A 20050411
- EP 05300319 A 20050426
- EP 06724173 A 20060410
Abstract (en)
[origin: WO2006108586A2] The invention relates to SAEP II peptide dimers that mimic polymyxin B i.a. in its ability to bind non-covalently the lipopolysaccharide (LPS) of Gram-negative bacteria with high affinity, and therefore to detoxify LPS as polymyxin B does. The dimeric structure is maintained by a pair of disulphide bonds involving the two cystein residues present in the peptide sequence, which does not exceed 17 amino acids and essentially comprises cationic and hydrophobic amino acid residues. In the dimers of the invention, peptides may have a parallel or anti-parallel orientation. As a matter of example, a dimer of the invention is constituted by a peptide of formula NH2-Lys-Thr-Lys-Cysl-Lys-Phe-Leu- Leu-Leu-Cys2-COOH, either in a parallel or antiparallel dimeric form. SAEP II dimers are useful for treating or preventing septic shock and related disorders generated by Gram-negative bacteria infection. The invention also relates to LPS-peptide complexes in which LPS and SAEP II dimers are non-covalently bound together. These complexes are useful as vaccinal agents against Gram-negative bacteria infection.
IPC 8 full level
C07K 7/08 (2006.01); A61K 38/10 (2006.01); A61K 38/16 (2006.01); C07K 14/195 (2006.01)
CPC (source: EP KR)
A61K 47/62 (2017.07 - EP); A61P 31/04 (2017.12 - EP); A61P 39/02 (2017.12 - EP); C07K 5/00 (2013.01 - KR); C07K 7/00 (2013.01 - KR); C07K 7/06 (2013.01 - EP)
Citation (search report)
See references of WO 2006108586A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006108586 A2 20061019; WO 2006108586 A3 20061214; AU 2006233634 A1 20061019; BR PI0610701 A2 20100720; CA 2603850 A1 20061019; EP 1871787 A2 20080102; IL 186322 A0 20080120; JP 2008537749 A 20080925; KR 20070118646 A 20071217; MX 2007012457 A 20071210; NO 20075753 L 20071109; NZ 561374 A 20090228
DOCDB simple family (application)
EP 2006003237 W 20060410; AU 2006233634 A 20060410; BR PI0610701 A 20060410; CA 2603850 A 20060410; EP 06724173 A 20060410; IL 18632207 A 20070925; JP 2008505786 A 20060410; KR 20077023738 A 20071016; MX 2007012457 A 20060410; NO 20075753 A 20071109; NZ 56137406 A 20060410