EP 1872134 A2 20080102 - REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN CARCINOMA SIGNALING PATHWAYS
Title (en)
REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN CARCINOMA SIGNALING PATHWAYS
Title (de)
REAGENTIEN ZUM NACHWEIS VON PROTEINPHOSPHORYLIERUNG IN KARZINOM-SIGNALWEGEN
Title (fr)
RÉACTIFS DE DÉTECTION DE PHOSPHORYLATION DE PROTÉINES DANS LA VOIE DE SIGNALISATION DE CARCINOME
Publication
Application
Priority
- US 2006010868 W 20060324
- US 67044705 P 20050412
Abstract (en)
[origin: WO2006113050A2] The invention discloses (214) novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeleton proteins, GTP Signaling proteins, Kinases, Metabolism proteins, Phosphatases/Phospho- diesterases/ Proteases, Receptor proteins, RNA Processing proteins, Transcription proteins, Translation proteins, Transporter proteins, and Ubitquitin proteins, as well as other protein types.
IPC 8 full level
G01N 33/53 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 16/44 (2006.01)
CPC (source: EP)
C07K 14/4748 (2013.01); C07K 16/44 (2013.01); G01N 33/57496 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
WO 2006113050 A2 20061026; WO 2006113050 A3 20081224; WO 2006113050 A4 20090326; WO 2006113050 A8 20071227; EP 1872134 A2 20080102; EP 1872134 A4 20100901
DOCDB simple family (application)
US 2006010868 W 20060324; EP 06739581 A 20060324