EP 1874332 A2 20080109 - IMMUNOGENIC EGFR PEPTIDES COMPRISING FOREIGN T CELL STIMULATING EPITOPE
Title (en)
IMMUNOGENIC EGFR PEPTIDES COMPRISING FOREIGN T CELL STIMULATING EPITOPE
Title (de)
IMMUNOGENE EGFR-PEPTIDE MIT FREMDEM T-ZELL-STIMULIERENDEN EPITOP
Title (fr)
PEPTIDES IMMUNOGENES DERIVES DU RECEPTEUR EGF COMPRENANT DES EPITOPES STIMULANT DES CELLULES T ALLOGENIQUES
Publication
Application
Priority
- DK 2006000184 W 20060330
- DK PA200500448 A 20050331
- US 66744105 P 20050331
Abstract (en)
[origin: WO2006102901A2] Disclosed is a method for inducing an immune response against autologous Epidermal Growth Factor Receptor (EGFR) in humans. The method comprises effecting uptake by antigen presenting cells of epitopes (preferably all) from the extracellular portion of human EGFR and of at least one non-human T helper epitope (TH epitope) so as to induce antibodies agains EGFR. Immunization may be accomplished by protein vaccination, nucleic acid vaccination and live or viral vaccination. The immune response is useful in treatment of malignancies. Also disclosed are modified EGFR proteins and expression plasmids useful for the immunization method as well as recombinant gene technology tools such as nucleic acids, vectors and host cells.
IPC 8 full level
A61K 38/17 (2006.01)
CPC (source: EP US)
A61K 9/0019 (2013.01 - EP US); A61K 39/001104 (2018.08 - EP US); A61K 48/00 (2013.01 - EP US); A61P 37/00 (2018.01 - EP); C07K 14/71 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); A61K 2039/53 (2013.01 - EP US); A61K 2039/55522 (2013.01 - EP US); A61K 2039/55527 (2013.01 - EP US); A61K 2039/6037 (2013.01 - EP US); A61K 2039/6043 (2013.01 - EP US); A61K 2039/6075 (2013.01 - EP US); Y02A 50/30 (2018.01 - US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
WO 2006102901 A2 20061005; WO 2006102901 A3 20070412; AU 2006228872 A1 20061005; CA 2603052 A1 20061005; EP 1874332 A2 20080109; IL 185699 A0 20080106; US 2008253993 A1 20081016
DOCDB simple family (application)
DK 2006000184 W 20060330; AU 2006228872 A 20060330; CA 2603052 A 20060330; EP 06722876 A 20060330; IL 18569907 A 20070904; US 90998306 A 20060330