EP 1874741 A1 20080109 - AZOLE DERIVATIVES IN THE FORM OF LIPASE AND PHOSPHOLIPASE INHIBITORS
Title (en)
AZOLE DERIVATIVES IN THE FORM OF LIPASE AND PHOSPHOLIPASE INHIBITORS
Title (de)
AZOLDERIVATE ALS INHIBITOREN VON LIPASEN UND PHOSPHOLIPASEN
Title (fr)
DERIVES D'AZOLE COMME INHIBITEURS DE LIPASES ET DE PHOSPHOLIPASES
Publication
Application
Priority
- EP 2006003411 W 20060413
- DE 102005018389 A 20050420
Abstract (en)
[origin: US2008090867A1] The invention relates to azole derivatives of the general formula I as defined in the present application as well as to their uses in treatment of conditions that would benefit from their inhibitory effect on hormone sensitive lipase, HSL, an allosteric enzyme in adipocytes which is inhibited by insulin and is responsible for the breakdown of fats in fat cells and thus for transferring fat constituents into the blood stream. Inhibition of this enzyme is therefore equivalent to an insulin-like effect of the compounds of the invention.
IPC 8 full level
C07D 261/20 (2006.01); A61K 31/423 (2006.01); A61K 31/428 (2006.01); A61K 31/437 (2006.01); A61K 31/454 (2006.01); A61P 3/10 (2006.01); C07D 275/04 (2006.01); C07D 413/12 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01)
CPC (source: EP KR US)
A61K 31/423 (2013.01 - KR); A61K 31/428 (2013.01 - KR); A61P 3/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 261/20 (2013.01 - EP US); C07D 275/04 (2013.01 - EP US); C07D 413/12 (2013.01 - EP US); C07D 498/04 (2013.01 - KR); C07D 513/04 (2013.01 - EP KR US)
Citation (search report)
See references of WO 2006111321A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
US 2008090867 A1 20080417; US 8921404 B2 20141230; AR 053228 A1 20070425; AU 2006237127 A1 20061026; BR PI0608495 A2 20100105; CA 2606301 A1 20061026; CN 101160293 A 20080409; DE 102005018389 A1 20061026; EP 1874741 A1 20080109; IL 186635 A0 20080120; JP 2008536884 A 20080911; KR 20080004501 A 20080109; MA 29393 B1 20080401; MX 2007012732 A 20080314; MY 142441 A 20101130; NO 20075938 L 20071119; NZ 562694 A 20100528; RU 2007142657 A 20090527; RU 2414458 C2 20110320; TW 200722421 A 20070616; WO 2006111321 A1 20061026; ZA 200707929 B 20081231
DOCDB simple family (application)
US 87384607 A 20071017; AR P060101521 A 20060418; AU 2006237127 A 20060413; BR PI0608495 A 20060413; CA 2606301 A 20060413; CN 200680012729 A 20060413; DE 102005018389 A 20050420; EP 06761897 A 20060413; EP 2006003411 W 20060413; IL 18663507 A 20071014; JP 2008506977 A 20060413; KR 20077024150 A 20071019; MA 30299 A 20071012; MX 2007012732 A 20060413; MY PI20061785 A 20060419; NO 20075938 A 20071119; NZ 56269406 A 20060413; RU 2007142657 A 20060413; TW 95113710 A 20060418; ZA 200707929 A 20070917