EP 1888067 A1 20080220 - COMBINATION THERAPY COMPRISING A DIARYL UREA COMPOUND AND A PI3, AKT KINASE OR MTOR INHIBITORS (RAPAMYCINS) FOR CANCER TREATMENT
Title (en)
COMBINATION THERAPY COMPRISING A DIARYL UREA COMPOUND AND A PI3, AKT KINASE OR MTOR INHIBITORS (RAPAMYCINS) FOR CANCER TREATMENT
Title (de)
KOMBINATIONSTHERAPIE MIT EINER DIARYLHARNSTOFFVERBINDUNG UND EINEM PI3-,AKT-KINASE- ODER MTOR-INHIBITOREN (RAPAMYCINEN) ZUR KREBSBEHANDLUNG
Title (fr)
TRAITEMENT DE COMBINAISON COMPRENANT UN COMPOSE DIARYLUREE ET DES INHIBITEURS DE PI3- OU AKT-KINASE OU DE MTOR (RAPAMYCINES) POUR LE TRAITEMENT DU CANCER
Publication
Application
Priority
- EP 2006004524 W 20060513
- EP 05011477 A 20050527
- EP 06724813 A 20060513
Abstract (en)
[origin: WO2006125540A1] The present invention relates to pharmaceutical compositions and combinations for treating cancer, comprising a diaryl urea compound e.g. 4 {4- [3- (4-chloro-3-trifluoromethylphenyl) -ureido] -3-fluorophenoxy}-pyridine-2- carboxylis acid methylamide and an PI3K/AKT signaling pathway inhibitor. The PI3K/AKI signaling pathway inhibitor comprises PI3 inhibitors {like celecoxilo, viridins, wortmannins} , AKT kinase inhibitors {like perifosine, triciribine} and mTOR inhibitors {like the rapamycins temsirolimus and evorolimus}.
IPC 8 full level
A61K 31/4412 (2006.01); A61K 31/436 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP KR)
A61K 31/436 (2013.01 - EP KR); A61K 31/4412 (2013.01 - EP KR); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); Y02A 50/30 (2017.12 - EP)
Citation (search report)
See references of WO 2006125540A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006125540 A1 20061130; AU 2006251429 A1 20061130; BR PI0610048 A2 20100525; CA 2609389 A1 20061130; CN 101257903 A 20080903; EP 1888067 A1 20080220; IL 187508 A0 20080605; JP 2008542214 A 20081127; KR 20080018908 A 20080228; MX 2007014726 A 20080214; RU 2007148266 A 20090710
DOCDB simple family (application)
EP 2006004524 W 20060513; AU 2006251429 A 20060513; BR PI0610048 A 20060513; CA 2609389 A 20060513; CN 200680018517 A 20060513; EP 06724813 A 20060513; IL 18750807 A 20071120; JP 2008512730 A 20060513; KR 20077030272 A 20071226; MX 2007014726 A 20060513; RU 2007148266 A 20060513