EP 1888111 A4 20081119 - MODULATION OF CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) ACTIVITY
Title (en)
MODULATION OF CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) ACTIVITY
Title (de)
MODULATION DER CHOLESTERINESTERTRANSFERPROTEIN (CETP)-AKTIVITÄT
Title (fr)
MODULATION DE L'ACTIVITÉ DE LA PROTÉINE DE TRANSFERT DE CHOLESTÉRYLESTER (CETP)
Publication
Application
Priority
- US 2006021927 W 20060606
- US 14578305 A 20050606
Abstract (en)
[origin: US2006276400A1] The present invention relates to autoantigenic vaccine peptides comprising a universal helper T cell epitope portion linked to a B cell epitope portion from the N-terminus of cholesteryl ester transfer protein (CETP). The vaccine peptides are useful for eliciting an autoimmune response in a vaccinated individual, i.e., raising antibodies against the individual's endogenous CETP, in turn modulating circulating CETP activity, reducing LDL-cholesterol levels, and increasing HDL-cholesterol levels, which in turn is helpful to treat cardiovascular disease, such as atherosclerosis.
IPC 8 full level
A61K 39/385 (2006.01); A61K 38/00 (2006.01); A61K 38/02 (2006.01); A61K 38/08 (2006.01); A61K 38/16 (2006.01); A61K 39/00 (2006.01); C07K 2/00 (2006.01); C07K 7/04 (2006.01); C07K 7/08 (2006.01); C07K 14/00 (2006.01); C07K 19/00 (2006.01)
CPC (source: EP US)
A61K 39/0005 (2013.01 - EP US); A61P 9/10 (2017.12 - EP); C07K 7/08 (2013.01 - EP US); C07K 16/18 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); A61K 2039/6037 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US); Y02A 50/30 (2017.12 - EP US)
Citation (search report)
- [X] US 2003021804 A1 20030130 - NEEDLEMAN PHILIP [US], et al
- [A] JP H06169793 A 19940621 - EIKEN CHEMICAL & DATABASE WPI Section Ch Week 199429, Derwent World Patents Index; Class B04, AN 237601, IMI T: "Monoclonal antibody recognise human lipid transfer protein useful immunoassay"
- [A] WO 9741227 A1 19971106 - T CELL SCIENCES INC [US], et al
- [A] SAITO K ET AL: "EPITOPE MAPPING FOR THE ANTI-RABBIT CHOLESTERYL ESTER TRANSFER PROTEIN MONOCLONAL ANTIBODY THAT SELECTIVELY INHIBITS TRIGLYCERIDE TRANSFER", JOURNAL OF LIPID RESEARCH, BETHESDA, MD, US, vol. 40, 1 January 1999 (1999-01-01), pages 2013 - 2021, XP002901716, ISSN: 0022-2275
- [A] KOTAKE HIDETOSHI ET AL: "Modification of the N-terminal cysteine of plasma cholesteryl ester transfer protein selectively inhibits triglyceride transfer activity", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1347, no. 1, 1997, pages 69 - 74, XP002498969, ISSN: 0006-3002
- See references of WO 2006133196A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
US 2006276400 A1 20061207; AU 2006255046 A1 20061214; CA 2609865 A1 20061214; EP 1888111 A1 20080220; EP 1888111 A4 20081119; JP 2008545759 A 20081218; WO 2006133196 A1 20061214
DOCDB simple family (application)
US 14578305 A 20050606; AU 2006255046 A 20060606; CA 2609865 A 20060606; EP 06772297 A 20060606; JP 2008514971 A 20060606; US 2006021927 W 20060606