EP 1891201 A2 20080227 - PHARMACOKINETIC-BASED CULTURE SYSTEM WITH BIOLOGICAL BARRIERS
Title (en)
PHARMACOKINETIC-BASED CULTURE SYSTEM WITH BIOLOGICAL BARRIERS
Title (de)
AUF PHARMAKOKINETIK BASIERENDES KULTURSYSTEM MIT BIOLOGISCHEN BARRIEREN
Title (fr)
SYSTEME DE CULTURE PHARMACOCINETIQUE PRESENTANT DES BARRIERES BIOLOGIQUES
Publication
Application
Priority
- US 2006018951 W 20060517
- US 68213105 P 20050518
Abstract (en)
[origin: WO2007021343A2] Systems and methods are disclosed for microscale pharmacokinetics. Various organs and their interactions with drug compounds can be simulated in vitro by use of microscale compartments (3722, 3734, 3744) that can be interconnected by microscale channels. Cells or cellular materials associated with the organs can be cultured in such compartments to allow interactions with drug compounds in one or more fluidic flows. Such fluidic systems can include, by way of examples, gastrointestinal flow, blood flow, bile flow, urinary flow, and brain fluid flow. Interactions between fluidic systems can be simulated by a microscale permeable member (3430). In one example, blood-biliary interaction can be simulated by a microscale permeable material having hepatocytes (3434) bound to a permeable substrate (3432) via a binder.
IPC 8 full level
CPC (source: EP)
C12M 21/08 (2013.01); C12M 23/16 (2013.01); C12M 23/44 (2013.01); C12M 29/04 (2013.01); B01L 3/5027 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007021343 A2 20070222; WO 2007021343 A3 20070621; CA 2607965 A1 20070222; CN 101223268 A 20080716; EP 1891201 A2 20080227; EP 1891201 A4 20111109; JP 2008539787 A 20081120
DOCDB simple family (application)
US 2006018951 W 20060517; CA 2607965 A 20060517; CN 200680025975 A 20060517; EP 06813188 A 20060517; JP 2008512445 A 20060517