EP 1893175 A1 20080305 - AQUEOUS SUSTAINED-RELEASE DRUG DELIVERY SYSTEM FOR HIGHLY WATER-SOLUBLE ELECTROLYTIC DRUGS
Title (en)
AQUEOUS SUSTAINED-RELEASE DRUG DELIVERY SYSTEM FOR HIGHLY WATER-SOLUBLE ELECTROLYTIC DRUGS
Title (de)
WÄSSRIGES ARZNEISTOFFABGABESYSTEM MIT ANHALTENDER WIRKSTOFFFREIGABE FÜR STARK WASSERLÖSLICHE ELEKTROLYTIKA
Title (fr)
SYSTEME AQUEUX D'APPORT DE MEDICAMENTS A LIBERATION CONTROLEE POUR MEDICAMENTS ELECTROLYTIQUES HAUTEMENT HYDROSOLUBLES
Publication
Application
Priority
US 2005020534 W 20050609
Abstract (en)
[origin: WO2006135362A1] The present invention relates to liquid sustained release suspension dosage forms comprising ionized forms of water-soluble drugs. In particular, the invention encompasses a liquid form controlled release drug composition comprising a dispersed phase comprising an ion-exchange matrix drug complex comprising a pharmaceutically acceptable a ion-exchange matrix and a water-soluble electrolytic drug associated with the ion-exchange matrix, wherein the surface charge of the ion-exchange matrix is opposite that of the electrolytic drug wherein the dispersed phase further comprises a non-electrolytic, soluble component having low molecular weight and a diffusion controlling membrane and a dispersion medium substantially free of diffusible counterions, further comprising an excipient capable of associating with water and impeding water activity such that drug dissolution is inhibited prior to administration. The invention also provides methods for preparing such compositions and methods of treatment.
IPC 8 full level
A61K 9/10 (2006.01); A61K 31/135 (2006.01); A61K 47/36 (2006.01); A61K 47/48 (2006.01)
CPC (source: EP)
A61K 9/0095 (2013.01); A61K 9/1635 (2013.01); A61K 9/1652 (2013.01); A61K 9/5026 (2013.01); A61K 31/135 (2013.01); A61K 47/585 (2017.07); A61P 11/08 (2017.12); A61K 9/5078 (2013.01)
Citation (search report)
See references of WO 2006135362A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR LV MK YU
DOCDB simple family (publication)
WO 2006135362 A1 20061221; WO 2006135362 A9 20140508; CA 2611190 A1 20061221; EP 1893175 A1 20080305; EP 2361611 A2 20110831; EP 2361611 A3 20111012; EP 2361612 A2 20110831; EP 2361612 A3 20111012; JP 2008543751 A 20081204
DOCDB simple family (application)
US 2005020534 W 20050609; CA 2611190 A 20050609; EP 05758570 A 20050609; EP 10015416 A 20050609; EP 10015417 A 20050609; JP 2008515675 A 20050609