Global Patent Index - EP 1893752 A2

EP 1893752 A2 20080305 - ATTENUATED SARS AND USE AS A VACCINE

Title (en)

ATTENUATED SARS AND USE AS A VACCINE

Title (de)

ABGESCHWÄCHTE SARS-COV IMPFSTOFFE

Title (fr)

SRAS ATTENUE: UTILISATION COMME VACCIN

Publication

EP 1893752 A2 20080305 (EN)

Application

EP 06762172 A 20060623

Priority

  • EP 2006006091 W 20060623
  • EP 05013727 A 20050624
  • EP 06762172 A 20060623

Abstract (en)

[origin: EP1736539A1] The present invention relates to nucleic acids encoding attenuated SARS-CoV viruses which are capable of producing a maximum viral titer in cell culture that is reduced at least by a factor of 2 when compared to the maximum viral titer of wild-type SARS-CoV virus in the same cell culture. According to a further aspect of the present invention, the nucleic acids encoding an attenuated SARS-CoV virus, are obtainable by a method comprising steps, wherein the genome of a SARS-CoV virus is modified by amending the sequence of the gene encoding the SARS-CoV E protein so that the nucleic acid cannot express a functional E protein. The present invention further relates to the viruses encoded by these nucleic acids as well as the medical use of the nucleic acids and of the viruses.

IPC 8 full level

C12N 7/04 (2006.01); A61K 39/215 (2006.01); A61P 11/00 (2006.01)

CPC (source: EP)

A61K 39/12 (2013.01); A61K 39/215 (2013.01); A61P 11/00 (2017.12); C07K 14/005 (2013.01); C12N 7/00 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/53 (2013.01); C12N 2770/20022 (2013.01); C12N 2770/20034 (2013.01); C12N 2770/20061 (2013.01)

Citation (search report)

See references of WO 2006136448A2

Citation (examination)

  • DEDIEGO MARTA L ET AL: "A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo", JOURNAL OF VIROLOGY, vol. 81, no. 4, February 2007 (2007-02-01), pages 1701 - 1713, ISSN: 0022-538X
  • DEDIEGO M L ET AL: "Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 376, no. 2, 5 July 2008 (2008-07-05), pages 379 - 389, XP022702078, ISSN: 0042-6822, [retrieved on 20080502], DOI: 10.1016/J.VIROL.2008.03.005
  • LAMIRANDE ELAINE W ET AL: "A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in Golden Syrian hamsters", JOURNAL OF VIROLOGY, vol. 82, no. 15, August 2008 (2008-08-01), pages 7721 - 7724, ISSN: 0022-538X
  • YOUNT BOYD ET AL: "Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice", JOURNAL OF VIROLOGY, vol. 79, no. 23, December 2005 (2005-12-01), pages 14909 - 14922, ISSN: 0022-538X

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

EP 1736539 A1 20061227; CN 101248174 A 20080820; EP 1893752 A2 20080305; WO 2006136448 A2 20061228; WO 2006136448 A3 20070719

DOCDB simple family (application)

EP 05013727 A 20050624; CN 200680031114 A 20060623; EP 06762172 A 20060623; EP 2006006091 W 20060623