Global Patent Index - EP 1894925 A1

EP 1894925 A1 20080305 - Imidazole compounds having an antiinflammatory effect

Title (en)

Imidazole compounds having an antiinflammatory effect

Title (de)

Imidazol Derivate mit entzündungshemmender Wirkung

Title (fr)

Derivés d'imidazole ayant une activité anti-inflammatoire

Publication

EP 1894925 A1 20080305 (EN)

Application

EP 06017677 A 20060824

Priority

EP 06017677 A 20060824

Abstract (en)

The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula I in which the radicals R 1 , R 2 , R 3 and R 4 have the meaning indicated in the description. The compounds of the invention have an immunomodulating and/or cytokine release-inhibiting effect and are therefore suitable for the treatment of disorders associated with an impairment of the immune system.

IPC 8 full level

C07D 401/14 (2006.01); A61K 31/4164 (2006.01); A61K 31/435 (2006.01); A61P 29/00 (2006.01); C07D 401/04 (2006.01)

CPC (source: EP US)

A61P 29/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); C07D 401/04 (2013.01 - EP US); C07D 401/14 (2013.01 - EP US); C07D 513/04 (2013.01 - EP US)

Citation (search report)

  • [E] WO 2006089798 A1 20060831 - MERCKLE GMBH [DE], et al
  • [DX] WO 2004018458 A1 20040304 - MERCKLE GMBH [DE], et al
  • [DX] WO 03097633 A1 20031127 - MERCKLE GMBH [DE], et al
  • [X] WO 02066458 A2 20020829 - MERCKLE GMBH [DE], et al
  • [X] LAUFER S A ET AL: "Tetrasubstituted Indazole inhibitors of Cytokine Release: probling Substituents in the N-1 Position", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 47, 10 November 2004 (2004-11-10), pages 6311 - 6325, XP002382670, ISSN: 0022-2623
  • [X] LAUFER S A ET AL: "Novel substituted Pyridinyl imidazoles as Potent Anticytokine Agents with Low Activity against Hepatic Cytochrome P450 Enzymes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 46, 24 June 2003 (2003-06-24), pages 3230 - 3244, XP002382671, ISSN: 0022-2623
  • [X] WAGNER G K ET AL: "Indentification of Regioisomers in a Series of N-Substituted Pyridin-4-yl Imidazole Derivatives by Regiospecific Synthesis, GC/MS, adn 1H NMR", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 68, 25 April 2003 (2003-04-25), pages 4527 - 4530, XP002382672, ISSN: 0022-3263

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK YU

DOCDB simple family (publication)

EP 1894925 A1 20080305; EP 2054404 A1 20090506; US 2010069436 A1 20100318; WO 2008023066 A1 20080228

DOCDB simple family (application)

EP 06017677 A 20060824; EP 07788537 A 20070824; EP 2007058847 W 20070824; US 31030507 A 20070824