Global Patent Index - EP 1895849 A4

EP 1895849 A4 20091111 - METHODS FOR TREATMENT OF BETA-AMYLOID PROTEIN-INDUCED OCULAR DISEASE

Title (en)

METHODS FOR TREATMENT OF BETA-AMYLOID PROTEIN-INDUCED OCULAR DISEASE

Title (de)

VERFAHREN FÜR DIE BEHANDLUNG VON BETA-AMYLOIDPROTEININDUZIERTE AUGENKRANKHEITEN

Title (fr)

PROCEDES POUR LE TRAITEMENT DE MALADIES OCULAIRES INDUITES PAR LES PROTEINES BETA-AMYLOIDIENNES

Publication

EP 1895849 A4 20091111 (EN)

Application

EP 06773171 A 20060614

Priority

  • US 2006023197 W 20060614
  • US 69081205 P 20050615
  • US 28708005 A 20051123
  • US 73979705 P 20051123

Abstract (en)

[origin: WO2006138399A1] The invention provides methods for treating beta-amyloid protein-involved ocular disease including age-related macular degeneration and glaucoma, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from Curcuma sp., Zingiber sp., Ginkgo biloba, Salvia sp., a

IPC 8 full level

A61K 31/05 (2006.01); A01N 65/00 (2009.01); A61K 31/343 (2006.01); A61K 31/352 (2006.01); A61K 31/60 (2006.01)

CPC (source: EP)

A61K 31/05 (2013.01); A61K 31/343 (2013.01); A61K 31/352 (2013.01); A61K 31/60 (2013.01); A61K 36/16 (2013.01); A61K 36/42 (2013.01); A61K 36/53 (2013.01); A61K 36/537 (2013.01); A61K 36/9068 (2013.01)

C-Set (source: EP)

  1. A61K 36/16 + A61K 2300/00
  2. A61K 36/42 + A61K 2300/00
  3. A61K 36/53 + A61K 2300/00
  4. A61K 36/537 + A61K 2300/00
  5. A61K 36/9068 + A61K 2300/00

Citation (search report)

  • [Y] WO 0130335 A2 20010503 - UNIV ILLINOIS [US], et al
  • [Y] BATE C ET AL: "Ginkgolide B inhibits the neurotoxicity of prions or amyloid-[beta] 1-42", JOURNAL OF NEUROINFLAMMATION 20040511 GB, vol. 1, 11 May 2004 (2004-05-11), XP002542118, ISSN: 1742-2094
  • [Y] YAO Z -X ET AL: "The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from [beta]-amyloid-induced cell death by inhibiting the formation of [beta]-amyloid-derived diffusible neurotoxic ligands", BRAIN RESEARCH 20010119 NL, vol. 889, no. 1-2, 19 January 2001 (2001-01-19), pages 181 - 190, XP002542119, ISSN: 0006-8993
  • [Y] KIM D S H L ET AL: "Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from [beta]A(1-42) insult", NEUROSCIENCE LETTERS 20010427 IE, vol. 303, no. 1, 27 April 2001 (2001-04-27), pages 57 - 61, XP002542120, ISSN: 0304-3940
  • [Y] KIM DARRICK S H L ET AL: "Side-chain length is important for shogaols in protecting neuronal cells from beta-amyloid insult.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 8 MAR 2004, vol. 14, no. 5, 8 March 2004 (2004-03-08), pages 1287 - 1289, XP002542121, ISSN: 0960-894X
  • [Y] KIM D S H L ET AL: "Shogaols from Zingiber officinale protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from [beta]amyloid(25-35) insult", PLANTA MEDICA 2002 DE, vol. 68, no. 4, 2002, pages 375 - 376, XP002542122, ISSN: 0032-0943
  • [Y] ONO K ET AL: "Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro", JOURNAL OF NEUROSCIENCE RESEARCH, WILEY-LISS, US, vol. 75, no. 6, 15 March 2004 (2004-03-15), pages 742 - 750, XP002989615, ISSN: 0360-4012
  • [Y] DENTCHEV T ET AL: "Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas", MOLECULAR VISION, MOLECULAR VISION, SN, ATLANTA, 1 September 2003 (2003-09-01), pages 184 - 190, XP003001744, ISSN: 1090-0535
  • [Y] JOHNSON L V ET AL: "The Alzheimer's Abeta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 99, no. 18, 3 September 2002 (2002-09-03), pages 11830 - 11835, XP003000979, ISSN: 0027-8424
  • [Y] MCKINNON STUART J: "Glaucoma: ocular Alzheimer's disease?", FRONTIERS IN BIOSCIENCE,, vol. 8, 1 September 2003 (2003-09-01), pages s1140 - s1156, XP009121526, ISSN: 1093-4715
  • [Y] JANCIAUSKIENE S ET AL: "Alzheimer's peptide and serine proteinase inhibitors in glaucoma and exfoliation syndrome", DOCUMENTA OPHTHALMOLOGICA 200305 NL, vol. 106, no. 3, May 2003 (2003-05-01), pages 215 - 223, XP002542123, ISSN: 0012-4486
  • [Y] PARK, SO-YOUNG: "Discovery of natural products from turmeric and sage that protect cells against beta-amyloid insult", DISSERTATION, 1 January 2001 (2001-01-01), Avail.: UMI, Order No. DA3008089 From: Diss. Abstr. Int., B 2001, 62(3), 1400, XP009121721
  • See references of WO 2006138399A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2006138399 A1 20061228; CA 2611490 A1 20061228; EP 1895849 A1 20080312; EP 1895849 A4 20091111

DOCDB simple family (application)

US 2006023197 W 20060614; CA 2611490 A 20060614; EP 06773171 A 20060614