EP 1897877 A2 20080312 - Crystalline forms of (R)-lanzoprazole
Title (en)
Crystalline forms of (R)-lanzoprazole
Title (de)
Kristallinische Formen von (R)-Lansoprazol
Title (fr)
Formes cristallines de (R)-lansoprazole
Publication
Application
Priority
- EP 01930131 A 20010515
- JP 2000141670 A 20000515
Abstract (en)
The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole · n'H 2 O (wherein n' is about 0 to about 0.1) or a salt thereof, which characteristically includes crystallization from an organic solvent solution or suspension in which (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-benzimidazole · nH 2 O (wherein n is about 0.1 to about 1.0) or a salt thereof has been dissolved or suspended, and the like, and provides a convenient method for efficiently producing an optically active sulfoxide derivative having an extremely high enantiomer excess in high yield at an industrial large scale.
IPC 8 full level
C07D 401/12 (2006.01); A61K 31/4439 (2006.01); A61P 1/04 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP KR US)
A61K 31/4439 (2013.01 - EP US); A61P 1/04 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07D 401/12 (2013.01 - EP KR US); C30B 7/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
EP 1293507 A1 20030319; EP 1293507 A4 20050907; EP 1293507 B1 20071128; AU 5673201 A 20011126; CA 2409044 A1 20021114; CA 2409044 C 20130219; CA 2701704 A1 20011122; CA 2701704 C 20110906; CA 2762960 A1 20011122; CA 2762960 C 20140722; CN 100562318 C 20091125; CN 1280287 C 20061018; CN 1437592 A 20030820; CN 1803137 A 20060719; CY 1107198 T1 20121121; DE 60131649 D1 20080110; DE 60131649 T2 20081030; DK 1293507 T3 20071227; EP 1897877 A2 20080312; EP 1897877 A3 20081210; EP 1897877 B1 20140924; EP 2281821 A1 20110209; EP 2281821 B1 20141022; ES 2293988 T3 20080401; ES 2511774 T3 20141023; ES 2521690 T3 20141113; KR 101035534 B1 20110523; KR 20080067713 A 20080721; KR 20090076980 A 20090713; PT 1293507 E 20080116; US 2003153766 A1 20030814; US 2007004779 A1 20070104; US 2010004458 A1 20100107; US 2011257405 A1 20111020; US 7169799 B2 20070130; US 7569696 B2 20090804; US 7994332 B2 20110809; US 8212046 B2 20120703; WO 0187874 A1 20011122
DOCDB simple family (application)
EP 01930131 A 20010515; AU 5673201 A 20010515; CA 2409044 A 20010515; CA 2701704 A 20010515; CA 2762960 A 20010515; CN 01811372 A 20010515; CN 200510131011 A 20010515; CY 081100182 T 20080214; DE 60131649 T 20010515; DK 01930131 T 20010515; EP 07120887 A 20010515; EP 10180351 A 20010515; ES 01930131 T 20010515; ES 07120887 T 20010515; ES 10180351 T 20010515; JP 0104014 W 20010515; KR 20087014246 A 20080613; KR 20097010290 A 20010515; PT 01930131 T 20010515; US 201113168121 A 20110624; US 27533402 A 20021107; US 49273509 A 20090626; US 51563906 A 20060905