EP 1897939 B1 20101103 - Microorganism strain for producing recombinant proteins
Title (en)
Microorganism strain for producing recombinant proteins
Title (de)
Mikroorganismenstamm zur Produktion von rekombinanten Proteinen
Title (fr)
Procédé destiné à la fabrication d'une broche
Publication
Application
Priority
DE 102006004871 A 20060202
Abstract (en)
[origin: DE102006004871A1] New microbial strain comprises a gene coding for a recombinant protein that is secreted during fermentation and a mutated gene that codes for a host protein and has a mutation such that expression of the host protein is reduced. Independent claims are also included for: (1) producing a microbial strain as above by transforming a host cells with the gene for the recombinant protein, culturing the cell in a fermentation medium so that the recombinant protein and host proteins are secreted into the medium, characterizing the host proteins, and reducing or preventing expression of a gene coding for one of the host proteins; (2) producing a recombinant protein by culturing a microbial strain as above in a fermentation medium and then separating the medium from the cells of the microbial strain.
IPC 8 full level
C12N 15/00 (2006.01); C12N 1/00 (2006.01); C12N 1/20 (2006.01); C12N 15/67 (2006.01)
CPC (source: EP US)
C12N 15/70 (2013.01 - EP US); C12P 21/02 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
EP 2298912 A2 20110323; EP 2298912 A3 20110928; AT E486935 T1 20101115; DE 102006004871 A1 20070809; DE 502007005530 D1 20101216; DK 1897939 T3 20110131; DK 2418276 T3 20140224; EP 1897939 A2 20080312; EP 1897939 A3 20080319; EP 1897939 B1 20101103; EP 2418276 A1 20120215; EP 2418276 B1 20131120; JP 2007202559 A 20070816; JP 4751347 B2 20110817; US 2008064062 A1 20080313; US 7749756 B2 20100706
DOCDB simple family (application)
EP 10175511 A 20070129; AT 07101292 T 20070129; DE 102006004871 A 20060202; DE 502007005530 T 20070129; DK 07101292 T 20070129; DK 10175512 T 20070129; EP 07101292 A 20070129; EP 10175512 A 20070129; JP 2007024736 A 20070202; US 70172507 A 20070202