EP 1899304 A1 20080319 - 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF
Title (en)
5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF
Title (de)
5-AMINO-1H-PYRAZOL-3-CARBONSÄUREDERIVATE ALS AGONISTEN DES G-PROTEIN-GEKOPPELTEN REZEPTORS (GPCR) RUP38 ZUR BEHANDLUNG VON STOFFWECHSELERKRANKUNGEN DAMIT
Title (fr)
DERIVES D'ACIDE 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIQUE EN TANT QU'AGONISTES DU RECEPTEUR COUPLE AUX PROTEINES G (RCPG) RUP38 POUR TRAITER DES TROUBLES LIES AU METABOLISME
Publication
Application
Priority
- US 2006019730 W 20060523
- US 68391205 P 20050523
Abstract (en)
[origin: WO2006127595A1] The present invention relates to certain pyrazole carboxylic acid or ester derivatives of Formula (I) and pharmaceutically acceptable salts thereof which exhibit useful pharmacological properties, for example, as agonists for the GPCR referred to herein as RUP38. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, such as, dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.
IPC 8 full level
C07D 231/38 (2006.01); A61K 31/415 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01)
CPC (source: EP)
A61P 3/00 (2017.12); A61P 3/04 (2017.12); A61P 3/06 (2017.12); A61P 3/10 (2017.12); C07D 231/38 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01)
Citation (search report)
See references of WO 2006127595A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
DOCDB simple family (application)
US 2006019730 W 20060523; EP 06770837 A 20060523