EP 1899308 B1 20121107 - TRIAZINES AS PROTEIN BINDING LIGANDS
Title (en)
TRIAZINES AS PROTEIN BINDING LIGANDS
Title (de)
TRIAZINE ALS PROTEINBINDUNGSLIGANDEN
Title (fr)
LIGANDS DE LIAISON DE PROTEINES
Publication
Application
Priority
- GB 2006050146 W 20060608
- GB 0511799 A 20050610
- US 69028705 P 20050614
Abstract (en)
[origin: WO2006131768A2] Compounds of the general formula (I): in which inter alia Q<SUP>1</SUP> represents -NR<SUP>1</SUP>R<SUP>3</SUP>, -OR<SUP>1</SUP> or -SR<SUP>1</SUP> and Q<SUP>2</SUP> represents -NR<SUP>2</SUP>R<SUP>4</SUP>, -OR<SUP>2</SUP> or -SR<SUP>2</SUP>, and A represents the point of attachment to a support matrix, are useful as protein binding ligands when (a) at least one of R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP> and R<SUP>4</SUP> includes an alkyl group -C<SUB>n</SUB>H<SUB>2n+1</SUB> in which n is greater than or equal to 7; (b) at least two of R<SUP>1</SUP> , R<SUP>2</SUP>, R<SUP>3</SUP> and R<SUP>4</SUP> independently include an alkyl group -C<SUB>n</SUB>H<SUB>2n+1</SUB> or a cycloalkyl group -C<SUB>n</SUB>H<SUB>2n-1</SUB> in which n is greater than or equal to 4; or (c) at least three of R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP> and R<SUP>4</SUP> independently include a C<SUB>1-12</SUB> alkyl group substituted by -NR<SUP>5</SUP>R<SUP>6</SUP> or aryl.
IPC 8 full level
C07D 251/44 (2006.01); B01D 15/38 (2006.01); B01J 20/286 (2006.01); B01J 20/32 (2006.01); C07D 251/50 (2006.01); C07D 251/70 (2006.01); C07K 1/20 (2006.01); G01N 30/00 (2006.01)
CPC (source: EP US)
B01D 15/3804 (2013.01 - EP US); B01J 20/3242 (2013.01 - EP US); B01J 20/3255 (2013.01 - EP US); C07D 251/44 (2013.01 - EP US); C07D 251/50 (2013.01 - EP US); C07D 251/70 (2013.01 - EP US); C07K 1/20 (2013.01 - EP US); B01D 15/327 (2013.01 - EP US); C07B 2200/11 (2013.01 - EP US); C40B 40/00 (2013.01 - EP US); Y10T 436/255 (2015.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006131768 A2 20061214; WO 2006131768 A3 20070927; BR PI0611811 A2 20081209; CA 2611734 A1 20061214; EP 1899308 A2 20080319; EP 1899308 B1 20121107; JP 2008545868 A 20081218; JP 5614930 B2 20141029; US 2008207876 A1 20080828; US 8501939 B2 20130806
DOCDB simple family (application)
GB 2006050146 W 20060608; BR PI0611811 A 20060608; CA 2611734 A 20060608; EP 06744347 A 20060608; JP 2008515296 A 20060608; US 91705306 A 20060608