EP 1899312 A2 20080319 - IMPROVED SYNTHESIS OF SUBSTITUTED 1-HALOMETHYL-2-PHENYL-1-PHENYL OXIRANE
Title (en)
IMPROVED SYNTHESIS OF SUBSTITUTED 1-HALOMETHYL-2-PHENYL-1-PHENYL OXIRANE
Title (de)
VERBESSERTE SYNTHESE VON SUBSTITUIERTEN 1-HALOGENMETHYL-2-PHENYL-1-PHENYLOXIRAMEN
Title (fr)
AMELIORATION DE LA SYNTHESE DU 1-HALOMETHYL-2-PHENYL-1-PHENYLOXYRANE SUBSTITUE
Publication
Application
Priority
- IL 2006000729 W 20060622
- IL 16942005 A 20050627
Abstract (en)
[origin: WO2007000759A2] The present invention provides an improved process for the preparation of 1-halomethyl-2-phenyl-1-phenyl oxirane, wherein the phenyl substituents may be mono-, di- or poly- halo substituted, wherein 3-halo-2-phenyl- 1-phenyl propene is reacted with an anhydride and hydrogen peroxide in a solvent selected from among alkyl esters, followed by subsequent extraction and separation of the organic phase and isolation of the oxirane. The improvements of said process are in yield, isolation procedure and safety. The isolation and purification of the oxirane is carried out subsequent to the reaction and includes extraction and crystallization in single, multiple or repeated stages.
IPC 8 full level
C07D 301/18 (2006.01)
CPC (source: EP KR)
C07D 301/18 (2013.01 - EP); C07D 303/08 (2013.01 - EP KR)
Citation (search report)
See references of WO 2007000759A2
Citation (examination)
DE 3218129 A1 19831117 - BASF AG [DE]
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007000759 A2 20070104; WO 2007000759 A3 20070405; BR PI0613843 A2 20110215; CN 101208322 A 20080625; EP 1899312 A2 20080319; KR 20080024207 A 20080317
DOCDB simple family (application)
IL 2006000729 W 20060622; BR PI0613843 A 20060622; CN 200680022975 A 20060622; EP 06745168 A 20060622; KR 20087001352 A 20080117