EP 1899478 A2 20080319 - IMPROVING ANTIBODY EXPRESSION USING VECTORS CONTAINING INSULATOR ELEMENTS
Title (en)
IMPROVING ANTIBODY EXPRESSION USING VECTORS CONTAINING INSULATOR ELEMENTS
Title (de)
VERBESSERTE ANTIKÖRPER-EXPRESSION ÜBER VEKTOREN MIT ISOLATIONSELEMENTEN
Title (fr)
PROCEDE POUR AMELIORER L'EXPRESSION D'ANTICORPS EN UTILISANT DES VECTEURS QUI CONTIENNENT DES ELEMENTS D'ISOLATION
Publication
Application
Priority
- US 2006022131 W 20060607
- US 68962305 P 20050610
Abstract (en)
[origin: WO2007021353A2] The present invention relates to the improved production of a therapeutic antibody comprising the use of insulator elements flanking the immunoglobulin sequence(s). Cell survival is also improved with the increase in the number of insulator elements.
IPC 8 full level
C12P 21/08 (2006.01)
CPC (source: EP)
C07K 14/4702 (2013.01); C07K 16/00 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 2007021353A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
WO 2007021353 A2 20070222; WO 2007021353 A3 20070830; AU 2006280428 A1 20070222; CA 2611465 A1 20070222; EP 1899478 A2 20080319; JP 2008543283 A 20081204; MX 2007015540 A 20080307
DOCDB simple family (application)
US 2006022131 W 20060607; AU 2006280428 A 20060607; CA 2611465 A 20060607; EP 06813200 A 20060607; JP 2008515874 A 20060607; MX 2007015540 A 20060607